Assessment of vestibular ototoxicity of ear drops by recording of vestibular evoked potentials to acceleration impulses

Jean Yves Sichel, Ron Eliashar, Meir Plotnik, Haim Sohmer, Josef Elidan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Introduction: The cochlear ototoxicity of several ear drops is well documented in the literature, but very few studies exist on the vestibular ototoxicity of these topical drugs. Goal of Study: To develop an animal model for the assessment of the vestibular ototoxicity of ear drops. Materials and Methods: Two animal groups, consisting of five fat sand rats (FSRs) each, underwent unilateral labyrinthectomy. Normal saline was topically applied into the middle ear cavity of rats in the first group for 7 days (control group). Rats in the second group were treated in the same way by topical gentamicin solution. Cochlear function was assessed by the recording of auditory evoked potential (ABPs) thresholds, and vestibular function was assessed by the recording of vestibular evoked potentials (VsEPs) to angular accelerations. Results: In the control group, except for the amplitude of the first wave, there was no significant difference in the VsEPs recorded before and after topical application. In the gentamicin group, VsEPs could not be recorded after 7 days, and ABPs were recorded in one case only, with a threshold of 100 dB, sound pressure level (SPL). Conclusion: VsEPs seem to be a reliable measure for evaluating the vestibular ototoxicity of topical ear drops.

Original languageEnglish
Pages (from-to)192-195
Number of pages4
JournalAmerican Journal of Otology
Volume21
Issue number2
StatePublished - Mar 2000
Externally publishedYes

Keywords

  • Auditory evoked potentials
  • Ear drops
  • Vestibular evoked potentials
  • Vestibular ototoxicity

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