Association between number of children and mortality of mothers: Results of a 37-year follow-up study

Uri P. Dior*, Hagit Hochner, Yechiel Friedlander, Ronit Calderon-Margalit, Dena Jaffe, Ayala Burger, Meytal Avgil, Orly Manor, Uriel Elchalal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Purpose: To examine the association between parity and long-term, all-cause mortality and mortality owing to specific causes in women. Methods: This prospective population-based study included 40,454 mothers who gave birth in Western Jerusalem, Israel, to 125,842 children and were followed for an average of 37 years after the birth of their first child. Cox proportional hazards models were used to evaluate long-term total and specific-cause mortality of women by their parity. Results: We found a U-shaped relationship between the number of offspring and risk of all-cause mortality in mothers. After adjustment for sociodemographic characteristics and maternal health and obstetric conditions, higher mortality rates were observed for mothers of 1 child (hazard ratio [HR], 1.18; 95% confidence interval [CI], 1.04-1.4), mothers of 5 to 9 children (HR, 1.21; 95% CI, 1.09-1.33), and mothers of 10 or more children (HR, 1.49; 95% CI, 1.12-1.99) compared with mothers of 2 to 4 children. Mortality risk from specific causes including coronary disease, circulatory disease, and cancer were increased for multiparous women. Conclusions: In this long-term follow-up study, there was an association between number of children and mortality risk for mothers. These findings suggest that maternal pregnancies and postnatal characteristics as reflected by number of children may have consequences for long-term maternal health.

Original languageAmerican English
Pages (from-to)13-18
Number of pages6
JournalAnnals of Epidemiology
Issue number1
StatePublished - Jan 2013
Externally publishedYes

Bibliographical note

Funding Information:
Funding: This work was supported by the National Institute of Health ( RO1 CA80197 ).


  • Mothers' mortality
  • Parity
  • Socioeconomic factors
  • Survival


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