Association of Mouse Major Histocompatibility and Rauscher Murine Leukaemia Virus Envelope Glycoprotein Antigens on Leukaemia Cells and their Recognition by Syngeneic Virus‐Immune‐Cytotoxic T‐Lymphocytes

D. A. ZARLING*, I. KESHET, A. WATSON, F. H. BACH

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Physical association was measured between MLV gp70, the envelope glycoprotein of Rauscher murine leukaemia virus (R‐MLV), and serologically defined H‐2 antigens on the surface of R‐MLV transformed C57BL/6 (H‐2Dbkb) mouse leukaemia cells (RBL‐5A). Capping and patching with antisera against H‐2Db caused specific co‐capping and co‐patching of R‐MLV gp70 antigens as seen by fluorescence microscopy. Despite the physical proximity of R‐MLV gp70 and H‐2Db antigens, high titre αR‐MLV gp70 sera had no effect in blocking syngeneic T‐lymphocyte mediated cytolysis of RBL‐5A cells whereas αaH‐2Db sera were effective.

Original languageEnglish
Pages (from-to)497-508
Number of pages12
JournalScandinavian Journal of Immunology
Volume8
Issue number6
DOIs
StatePublished - Dec 1978
Externally publishedYes

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