TY - JOUR
T1 - Associations of Adolescence Exposure to Industrial Air Pollution with Cancer in Young Adults
AU - Lev Bar-Or, Ruth
AU - Yuval, None
AU - Twig, Gilad
AU - Broday, David M.
AU - Keinan-Boker, Lital
AU - Paltiel, Ora
AU - Sinnreich, Ronit
AU - Tzur, Dorit
AU - Derazne, Estela
AU - Raz, Raanan
N1 - Publisher Copyright:
© 2023 The Authors. Co-published by Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, and American Chemical Society.
PY - 2023/7/21
Y1 - 2023/7/21
N2 - There is substantial public concern about the health risks of proximity to petrochemical industries. In the Haifa Bay Area (HBA), which contains Israel’s densest industrial area, these concerns have been strengthened by elevated cancer mortality rates since the late 1960s. We studied the association between adolescent exposure to industrial air pollution in the HBA and adult-onset cancer. This is a historical cohort study. The study population comprised 2,187,317 subjects, using the Israeli medical corps data linked to the Israel National Cancer Registry with follow-up of up to 45 years. Exposure assessments were estimated by a spatial kriging interpolation model of SO2, serving as a marker for the dispersion of air pollution emitted from the complex during the study period. We found increased crude (HR = 1.23, 95%CI= 1.17 to 1.29) and adjusted (HR = 1.16, 95%CI = 1.10 to 1.21) risk of cancer with increased exposure to air pollution in HBA. The associations remained robust in analyses stratified by decade and socio-economic status. We found evidence of monotonically increased risk in five of 13 cancer categories (leukemia, melanoma, female breast, central nervous system, and thyroid tumors). Our findings strengthen the hypothesis that this exposure posed a carcinogenic risk during the study period.
AB - There is substantial public concern about the health risks of proximity to petrochemical industries. In the Haifa Bay Area (HBA), which contains Israel’s densest industrial area, these concerns have been strengthened by elevated cancer mortality rates since the late 1960s. We studied the association between adolescent exposure to industrial air pollution in the HBA and adult-onset cancer. This is a historical cohort study. The study population comprised 2,187,317 subjects, using the Israeli medical corps data linked to the Israel National Cancer Registry with follow-up of up to 45 years. Exposure assessments were estimated by a spatial kriging interpolation model of SO2, serving as a marker for the dispersion of air pollution emitted from the complex during the study period. We found increased crude (HR = 1.23, 95%CI= 1.17 to 1.29) and adjusted (HR = 1.16, 95%CI = 1.10 to 1.21) risk of cancer with increased exposure to air pollution in HBA. The associations remained robust in analyses stratified by decade and socio-economic status. We found evidence of monotonically increased risk in five of 13 cancer categories (leukemia, melanoma, female breast, central nervous system, and thyroid tumors). Our findings strengthen the hypothesis that this exposure posed a carcinogenic risk during the study period.
KW - Haifa Bay Area
KW - cancer
KW - epidemiology
KW - industrial air pollution
KW - public health
UR - http://www.scopus.com/inward/record.url?scp=85173586804&partnerID=8YFLogxK
U2 - 10.1021/envhealth.3c00030
DO - 10.1021/envhealth.3c00030
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C2 - 39474627
AN - SCOPUS:85173586804
SN - 2833-8278
VL - 1
SP - 53
EP - 62
JO - Environment and Health
JF - Environment and Health
IS - 1
ER -
