Astaxanthin supplementation impacts the cellular HSP expression profile during passive heating

Chen Fleischmann*, Netta Bar-Ilan, Michal Horowitz, Yaron Bruchim, Patricia Deuster, Yuval Heled

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Astaxanthin is a powerful carotenoid antioxidant prevalent in marine organisms and approved as a food supplement. Recent studies have demonstrated Astaxanthin’s beneficial attributes in various health states. Following initial reports of potential heat protective properties in Astaxanthin supplemented rats, we present here results of a novel study examining the effect of Astaxanthin supplementation on the heat shock response in rats in relation to core temperature (Tc) and the ensuing physiological strain. Two hours of heat stress at 41 °C during which rats developed their thermoregulatory hyperthermic plateau resulted in progressive increases in HSP72 and HSP27 in the Astaxanthin (Oleoresin)-treated group but not in the control (Olive oil) group. Enhanced elevation in HSPs suggests that Astaxanthin supplementation may augment the cellular stress protective response to heat stress.

Original languageEnglish
Pages (from-to)549-558
Number of pages10
JournalCell Stress and Chaperones
Volume25
Issue number3
DOIs
StatePublished - 1 May 2020

Bibliographical note

Publisher Copyright:
© 2020, Cell Stress Society International.

Keywords

  • Astaxanthin
  • Environmental physiology
  • Heat stress
  • Nutritional pre-treatment

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