Astrocytes control recent and remote memory strength by affecting the recruitment of the CA1→ACC projection to engrams

Ron Refaeli, Tirzah Kreisel, Tamar Ravins Yaish, Maya Groysman, Inbal Goshen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The maturation of engrams from recent to remote time points involves the recruitment of CA1 neurons projecting to the anterior cingulate cortex (CA1→ACC). Modifications of G-protein-coupled receptor pathways in CA1 astrocytes affect recent and remote recall in seemingly contradictory ways. To address this inconsistency, we manipulated these pathways in astrocytes during memory acquisition and tagged c-Fos-positive engram cells and CA1→ACC cells during recent and remote recall. The behavioral results were coupled with changes in the recruitment of CA1→ACC projection cells to the engram: Gq pathway activation in astrocytes caused enhancement of recent recall alone and was accompanied by earlier recruitment of CA1→ACC projecting cells to the engram. In contrast, Gi pathway activation in astrocytes resulted in the impairment of only remote recall, and CA1→ACC projecting cells were not recruited during remote memory. Finally, we provide a simple working model, hypothesizing that Gq and Gi pathway activation affect memory differently, by modulating the same mechanism: CA1→ACC projection.

Original languageAmerican English
Article number113943
JournalCell Reports
Volume43
Issue number3
DOIs
StatePublished - 26 Mar 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s)

Keywords

  • anterior cingulate cortex
  • astrocytes
  • CLARITY
  • CP: Neuroscience
  • fear-conditioning
  • Gq-pathway
  • hippocampus
  • recent memory
  • remote memory

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