Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement

Adar Adamsky, Adi Kol, Tirzah Kreisel, Adi Doron, Nofar Ozeri-Engelhard, Talia Melcer, Ron Refaeli, Henrike Horn, Limor Regev, Maya Groysman, Michael London, Inbal Goshen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

352 Scopus citations

Abstract

Astrocytes respond to neuronal activity and were shown to be necessary for plasticity and memory. To test whether astrocytic activity is also sufficient to generate synaptic potentiation and enhance memory, we expressed the Gq-coupled receptor hM3Dq in CA1 astrocytes, allowing their activation by a designer drug. We discovered that astrocytic activation is not only necessary for synaptic plasticity, but also sufficient to induce NMDA-dependent de novo long-term potentiation in the hippocampus that persisted after astrocytic activation ceased. In vivo, astrocytic activation enhanced memory allocation; i.e., it increased neuronal activity in a task-specific way only when coupled with learning, but not in home-caged mice. Furthermore, astrocytic activation using either a chemogenetic or an optogenetic tool during acquisition resulted in memory recall enhancement on the following day. Conversely, directly increasing neuronal activity resulted in dramatic memory impairment. Our findings that astrocytes induce plasticity and enhance memory may have important clinical implications for cognitive augmentation treatments.

Original languageAmerican English
Pages (from-to)59-71.e14
JournalCell
Volume174
Issue number1
DOIs
StatePublished - 28 Jun 2018

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Inc.

Keywords

  • LTP
  • OptoXR
  • cFos
  • calcium imaging
  • chemogenetics
  • fear conditioning
  • hippocampus
  • memory allocation
  • miniature EPSCs
  • optogenetics

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