Abstract
Developmental programming is carried out by a sequence of molecular choices that epigenetically mark the genome to generate the stable cell types which make up the total organism. A number of important processes, such as genomic imprinting, selection of immune or olfactory receptors, and X-chromosome inactivation in females are dependent on the ability to stably choose one single allele in each cell. In this perspective, we propose that asynchronous replication timing (ASRT) serves as the basis for a sophisticated universal mechanism for mediating and maintaining these decisions.
| Original language | American English |
|---|---|
| Article number | 737681 |
| Pages (from-to) | 1-10 |
| Journal | Frontiers in Cell and Developmental Biology |
| Volume | 9 |
| DOIs | |
| State | Published - 1 Oct 2021 |
Bibliographical note
Funding Information:We thank our students and collaborators who participated in this research, especially Hagit Masika, Marganit Farago, Britny Blumenfeld, Lamia Halaseh, and Rachel Rapoport, the members of the Core Research Facility in the Hebrew University School of Medicine; Dan Lehmann and Eleonora Medvedev for assistance with the FACS analysis; Idit Shiff, Abed Nasereddin, and Alexia Azoulay for generating genomic data.
Funding Information:
This work was supported by research grants from the Israel Science Foundation (grants #734/13 and #1228/18 to YB, grant #282/16 to HC, grants #184/16 and #1283/21 to IS), ISF-NSFC (grant #2555/16 to IS), the Israel Cancer Research Foundation (IS and grant #211410 to YB, grant #210910 to HC), the Binational Science Foundation (grant #2100289 to YB, grant #2019688 to
Publisher Copyright:
© Copyright © 2021 Bergman, Simon and Cedar.
Keywords
- DNA replication
- X-chromosome inactivation
- chromatin accessibility
- embryonal stem cells
- epigenetic regulation
- genomic imprinting