Developmental programming is carried out by a sequence of molecular choices that epigenetically mark the genome to generate the stable cell types which make up the total organism. A number of important processes, such as genomic imprinting, selection of immune or olfactory receptors, and X-chromosome inactivation in females are dependent on the ability to stably choose one single allele in each cell. In this perspective, we propose that asynchronous replication timing (ASRT) serves as the basis for a sophisticated universal mechanism for mediating and maintaining these decisions.
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© Copyright © 2021 Bergman, Simon and Cedar.
- DNA replication
- X-chromosome inactivation
- chromatin accessibility
- embryonal stem cells
- epigenetic regulation
- genomic imprinting