TY - JOUR
T1 - Asynchronous Replication Timing
T2 - A Mechanism for Monoallelic Choice During Development
AU - Bergman, Yehudit
AU - Simon, Itamar
AU - Cedar, Howard
N1 - Publisher Copyright:
© Copyright © 2021 Bergman, Simon and Cedar.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Developmental programming is carried out by a sequence of molecular choices that epigenetically mark the genome to generate the stable cell types which make up the total organism. A number of important processes, such as genomic imprinting, selection of immune or olfactory receptors, and X-chromosome inactivation in females are dependent on the ability to stably choose one single allele in each cell. In this perspective, we propose that asynchronous replication timing (ASRT) serves as the basis for a sophisticated universal mechanism for mediating and maintaining these decisions.
AB - Developmental programming is carried out by a sequence of molecular choices that epigenetically mark the genome to generate the stable cell types which make up the total organism. A number of important processes, such as genomic imprinting, selection of immune or olfactory receptors, and X-chromosome inactivation in females are dependent on the ability to stably choose one single allele in each cell. In this perspective, we propose that asynchronous replication timing (ASRT) serves as the basis for a sophisticated universal mechanism for mediating and maintaining these decisions.
KW - DNA replication
KW - X-chromosome inactivation
KW - chromatin accessibility
KW - embryonal stem cells
KW - epigenetic regulation
KW - genomic imprinting
UR - http://www.scopus.com/inward/record.url?scp=85117119380&partnerID=8YFLogxK
U2 - 10.3389/fcell.2021.737681
DO - 10.3389/fcell.2021.737681
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AN - SCOPUS:85117119380
SN - 2296-634X
VL - 9
JO - Frontiers in Cell and Developmental Biology
JF - Frontiers in Cell and Developmental Biology
M1 - 737681
ER -