Asynchronous Replication Timing: A Mechanism for Monoallelic Choice During Development

Yehudit Bergman*, Itamar Simon, Howard Cedar

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Developmental programming is carried out by a sequence of molecular choices that epigenetically mark the genome to generate the stable cell types which make up the total organism. A number of important processes, such as genomic imprinting, selection of immune or olfactory receptors, and X-chromosome inactivation in females are dependent on the ability to stably choose one single allele in each cell. In this perspective, we propose that asynchronous replication timing (ASRT) serves as the basis for a sophisticated universal mechanism for mediating and maintaining these decisions.

Original languageAmerican English
Article number737681
JournalFrontiers in Cell and Developmental Biology
Volume9
DOIs
StatePublished - 1 Oct 2021

Bibliographical note

Publisher Copyright:
© Copyright © 2021 Bergman, Simon and Cedar.

Keywords

  • DNA replication
  • X-chromosome inactivation
  • chromatin accessibility
  • embryonal stem cells
  • epigenetic regulation
  • genomic imprinting

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