Atherosclerosis in the apolipoprotein E-deficient mouse: A decade of progress

Karen S. Meir, Eran Leitersdorf*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

433 Scopus citations

Abstract

Arguably the most critical advancement in the elucidation of factors affecting atherogenesis has been the development of mouse models of atherosclerosis. Among available models, the apolipoprotein E-deficient (apoE-/-) mouse is particularly popular because of its propensity to spontaneously develop atherosclerotic lesions on a standard chow diet. A Medline search reveals over 645 articles dedicated to studies using this reliable and convenient "super" animal model since its inception (Piedrahita JA et al, Proc Natl Acad Sci USA 1992;89:4471-4475; Plump AS et al, Cell 1992;71:343-353) with a more or less steady increase from year to year. This review will examine our present understanding of the pathology and progression of plaques in this animal and highlight some of the nutritional, pharmacological, and genetic studies that have enhanced this understanding.

Original languageEnglish
Pages (from-to)1006-1014
Number of pages9
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume24
Issue number6
DOIs
StatePublished - Jun 2004
Externally publishedYes

Keywords

  • Apolipoprotein E
  • Atherosclerosis
  • Knockout
  • Mouse model

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