TY - JOUR
T1 - Atherosclerosis in the apolipoprotein E-deficient mouse
T2 - A decade of progress
AU - Meir, Karen S.
AU - Leitersdorf, Eran
PY - 2004/6
Y1 - 2004/6
N2 - Arguably the most critical advancement in the elucidation of factors affecting atherogenesis has been the development of mouse models of atherosclerosis. Among available models, the apolipoprotein E-deficient (apoE-/-) mouse is particularly popular because of its propensity to spontaneously develop atherosclerotic lesions on a standard chow diet. A Medline search reveals over 645 articles dedicated to studies using this reliable and convenient "super" animal model since its inception (Piedrahita JA et al, Proc Natl Acad Sci USA 1992;89:4471-4475; Plump AS et al, Cell 1992;71:343-353) with a more or less steady increase from year to year. This review will examine our present understanding of the pathology and progression of plaques in this animal and highlight some of the nutritional, pharmacological, and genetic studies that have enhanced this understanding.
AB - Arguably the most critical advancement in the elucidation of factors affecting atherogenesis has been the development of mouse models of atherosclerosis. Among available models, the apolipoprotein E-deficient (apoE-/-) mouse is particularly popular because of its propensity to spontaneously develop atherosclerotic lesions on a standard chow diet. A Medline search reveals over 645 articles dedicated to studies using this reliable and convenient "super" animal model since its inception (Piedrahita JA et al, Proc Natl Acad Sci USA 1992;89:4471-4475; Plump AS et al, Cell 1992;71:343-353) with a more or less steady increase from year to year. This review will examine our present understanding of the pathology and progression of plaques in this animal and highlight some of the nutritional, pharmacological, and genetic studies that have enhanced this understanding.
KW - Apolipoprotein E
KW - Atherosclerosis
KW - Knockout
KW - Mouse model
UR - http://www.scopus.com/inward/record.url?scp=2942520978&partnerID=8YFLogxK
U2 - 10.1161/01.ATV.0000128849.12617.f4
DO - 10.1161/01.ATV.0000128849.12617.f4
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C2 - 15087308
AN - SCOPUS:2942520978
SN - 1079-5642
VL - 24
SP - 1006
EP - 1014
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
IS - 6
ER -