Attachment of drugs to polydimethylsiloxanes

A. Bachrach*, A. Zilkha

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Polydimethylsiloxane, which is a biologically inert polymer, was used as a carrier polymer for drugs. Functional groups were introduced into the polymer to enable attachment to drugs. Polymers (and oligomers) having carboxyl, amine or hydroxyl groups were prepared from polydimethylsiloxanes having different distributions of SiH groups which were added to the C=C double bond of unsaturated acids, amines or alcohols. These polymers were reacted with suitable functional groups on drugs such as digoxin, quinidine, barbiturates, amphetamine, naloxone and atropine.

Original languageEnglish
Pages (from-to)493-500
Number of pages8
JournalEuropean Polymer Journal
Volume20
Issue number5
DOIs
StatePublished - 1984

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