TY - JOUR
T1 - Attachment of drugs to polydimethylsiloxanes
AU - Bachrach, A.
AU - Zilkha, A.
PY - 1984
Y1 - 1984
N2 - Polydimethylsiloxane, which is a biologically inert polymer, was used as a carrier polymer for drugs. Functional groups were introduced into the polymer to enable attachment to drugs. Polymers (and oligomers) having carboxyl, amine or hydroxyl groups were prepared from polydimethylsiloxanes having different distributions of SiH groups which were added to the C=C double bond of unsaturated acids, amines or alcohols. These polymers were reacted with suitable functional groups on drugs such as digoxin, quinidine, barbiturates, amphetamine, naloxone and atropine.
AB - Polydimethylsiloxane, which is a biologically inert polymer, was used as a carrier polymer for drugs. Functional groups were introduced into the polymer to enable attachment to drugs. Polymers (and oligomers) having carboxyl, amine or hydroxyl groups were prepared from polydimethylsiloxanes having different distributions of SiH groups which were added to the C=C double bond of unsaturated acids, amines or alcohols. These polymers were reacted with suitable functional groups on drugs such as digoxin, quinidine, barbiturates, amphetamine, naloxone and atropine.
UR - http://www.scopus.com/inward/record.url?scp=0009725347&partnerID=8YFLogxK
U2 - 10.1016/0014-3057(84)90032-6
DO - 10.1016/0014-3057(84)90032-6
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AN - SCOPUS:0009725347
SN - 0014-3057
VL - 20
SP - 493
EP - 500
JO - European Polymer Journal
JF - European Polymer Journal
IS - 5
ER -