TY - JOUR
T1 - Attachment of drugs to polyethylene glycols
AU - Zalipsky, S.
AU - Gilon, C.
AU - Zilkha, A.
PY - 1983
Y1 - 1983
N2 - Polyethylene glycol (PEG) was used as a carrier polymer for the attachment, via end groups, of drugs such as penicillin V, aspirin, amphetamine, quinidine and atropine. For this purpose, methods were developed for the functionalization of PEG; PEG-NH2, PEG-COOH and PEG-NCO were prepared. Use was made of dicyclohexyl carbodiimide together with 4-dimethylamino pyridine or 1-hydroxybenzotriazole for the coupling reactions.
AB - Polyethylene glycol (PEG) was used as a carrier polymer for the attachment, via end groups, of drugs such as penicillin V, aspirin, amphetamine, quinidine and atropine. For this purpose, methods were developed for the functionalization of PEG; PEG-NH2, PEG-COOH and PEG-NCO were prepared. Use was made of dicyclohexyl carbodiimide together with 4-dimethylamino pyridine or 1-hydroxybenzotriazole for the coupling reactions.
UR - http://www.scopus.com/inward/record.url?scp=0001039302&partnerID=8YFLogxK
U2 - 10.1016/0014-3057(83)90016-2
DO - 10.1016/0014-3057(83)90016-2
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AN - SCOPUS:0001039302
SN - 0014-3057
VL - 19
SP - 1177
EP - 1183
JO - European Polymer Journal
JF - European Polymer Journal
IS - 12
ER -