Attachment of drugs to polyethylene glycols

S. Zalipsky; C. Gilon; A. Zilkha

doi:10.1016/0014-3057(83)90016-2

Attachment of drugs to polyethylene glycols

S. Zalipsky^*
, C. Gilon
, A. Zilkha

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

351 Scopus citations

Abstract

Polyethylene glycol (PEG) was used as a carrier polymer for the attachment, via end groups, of drugs such as penicillin V, aspirin, amphetamine, quinidine and atropine. For this purpose, methods were developed for the functionalization of PEG; PEG-NH₂, PEG-COOH and PEG-NCO were prepared. Use was made of dicyclohexyl carbodiimide together with 4-dimethylamino pyridine or 1-hydroxybenzotriazole for the coupling reactions.

Original language	English
Pages (from-to)	1177-1183
Number of pages	7
Journal	European Polymer Journal
Volume	19
Issue number	12
DOIs	https://doi.org/10.1016/0014-3057(83)90016-2
State	Published - 1983

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10.1016/0014-3057(83)90016-2

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title = "Attachment of drugs to polyethylene glycols",

abstract = "Polyethylene glycol (PEG) was used as a carrier polymer for the attachment, via end groups, of drugs such as penicillin V, aspirin, amphetamine, quinidine and atropine. For this purpose, methods were developed for the functionalization of PEG; PEG-NH2, PEG-COOH and PEG-NCO were prepared. Use was made of dicyclohexyl carbodiimide together with 4-dimethylamino pyridine or 1-hydroxybenzotriazole for the coupling reactions.",

author = "S. Zalipsky and C. Gilon and A. Zilkha",

year = "1983",

doi = "10.1016/0014-3057(83)90016-2",

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AU - Zalipsky, S.

AU - Gilon, C.

AU - Zilkha, A.

PY - 1983

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N2 - Polyethylene glycol (PEG) was used as a carrier polymer for the attachment, via end groups, of drugs such as penicillin V, aspirin, amphetamine, quinidine and atropine. For this purpose, methods were developed for the functionalization of PEG; PEG-NH2, PEG-COOH and PEG-NCO were prepared. Use was made of dicyclohexyl carbodiimide together with 4-dimethylamino pyridine or 1-hydroxybenzotriazole for the coupling reactions.

AB - Polyethylene glycol (PEG) was used as a carrier polymer for the attachment, via end groups, of drugs such as penicillin V, aspirin, amphetamine, quinidine and atropine. For this purpose, methods were developed for the functionalization of PEG; PEG-NH2, PEG-COOH and PEG-NCO were prepared. Use was made of dicyclohexyl carbodiimide together with 4-dimethylamino pyridine or 1-hydroxybenzotriazole for the coupling reactions.

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JO - European Polymer Journal

JF - European Polymer Journal

IS - 12

ER -

Attachment of drugs to polyethylene glycols

Abstract

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