ATTRITION OF TRISOMIES AS A MATERNAL SCREENING DEVICE. An Explanation of the Association of Trisomy 21 with Maternal Age

Zena Stein*, Wilfred Stein, Mervyn Susser

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Analysis of published data indicates that the increased rate of trisomy 21 pregnancies with advancing maternal age is due to failure of a postulated maternal screening process between fertilisation and recognition. This mechanism may also operate in other trisomies.

Original languageEnglish
Pages (from-to)944-947
Number of pages4
JournalThe Lancet
Volume327
Issue number8487
DOIs
StatePublished - 26 Apr 1986

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