Auranofin inhibits histamine release from rat peritoneal mast cells

Meir Shalit, Francesca Levi-Schaffer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The effect of auranofin on histamine release from immunologic and non-immunologic activated rat peritoneal mast cells cocultured with 3T3 fibroblasts (MC/3T3) was investigated. When MC/3T3 were preincubated with 2 × 10-5 M auranofin and thereafter challenged with anti-IgE antibodies, a maximal inhibition of histamine release (86.2%) was obtained. Non-immunological histamine release induced by compound 48/80, substance P and bradykinin was inhibited to a lesser degree, i.e. 36.0%, 37.6% and 24.0% respectively. Simultaneous incubation of auranofin and the stimulating agents resulted in a higher inhibition of histamine release: anti-IgE antibodies - 92.0%; compound 48/80 - 73.5%; substance P - 46.1%. We conclude that auranofin effectively reduces histamine release from immunologic and non-immunologic activated mast cells. This may be relevant to the control of allergic reactions.

Original languageAmerican English
Pages (from-to)403-407
Number of pages5
JournalInternational Journal of Immunopharmacology
Volume12
Issue number4
DOIs
StatePublished - 1990

Bibliographical note

Funding Information:
Acknowledgements -- This work was supported by a joint grant of the Hebrew University Hadassah Medical School. We wish to thank Mrs Ana Fibach for her skilful secretarial help.

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