TY - JOUR
T1 - Autism symptoms in attention-deficit/hyperactivity disorder
T2 - A familial trait which correlates with conduct, oppositional defiant, language and motor disorders
AU - Mulligan, Aisling
AU - Anney, Richard J.L.
AU - O'Regan, Myra
AU - Chen, Wai
AU - Butler, Louise
AU - Fitzgerald, Michael
AU - Buitelaar, Jan
AU - Steinhausen, Hans Christoph
AU - Rothenberger, Aribert
AU - Minderaa, Ruud
AU - Nijmeijer, Judith
AU - Hoekstra, Pieter J.
AU - Oades, Robert D.
AU - Roeyers, Herbert
AU - Buschgens, Cathelijne
AU - Christiansen, Hanna
AU - Franke, Barbara
AU - Gabriels, Isabel
AU - Hartman, Catharina
AU - Kuntsi, Jonna
AU - Marco, Rafaela
AU - Meidad, Sheera
AU - Mueller, Ueli
AU - Psychogiou, Lamprini
AU - Rommelse, Nanda
AU - Thompson, Margaret
AU - Uebel, Henrik
AU - Banaschewski, Tobias
AU - Ebstein, Richard
AU - Eisenberg, Jacques
AU - Manor, Iris
AU - Miranda, Ana
AU - Mulas, Fernando
AU - Sergeant, Joseph
AU - Sonuga-Barke, Edmund
AU - Asherson, Phil
AU - Faraone, Stephen V.
AU - Gill, Michael
PY - 2009/2
Y1 - 2009/2
N2 - It is hypothesised that autism symptoms are present in Attention-Deficit/ Hyperactivity Disorder (ADHD), are familial and index subtypes of ADHD. Autism symptoms were compared in 821 ADHD probands, 1050 siblings and 149 controls. Shared familiality of autism symptoms and ADHD was calculated using DeFries-Fulker analysis. Autism symptoms were higher in probands than siblings or controls, and higher in male siblings than male controls. Autism symptoms were familial, partly shared with familiality of ADHD in males. Latent class analysis using SCQ-score yielded five classes; Class 1(31%) had few autism symptoms and low comorbidity; Classes 2-4 were intermediate; Class 5(7%) had high autism symptoms and comorbidity. Thus autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders.
AB - It is hypothesised that autism symptoms are present in Attention-Deficit/ Hyperactivity Disorder (ADHD), are familial and index subtypes of ADHD. Autism symptoms were compared in 821 ADHD probands, 1050 siblings and 149 controls. Shared familiality of autism symptoms and ADHD was calculated using DeFries-Fulker analysis. Autism symptoms were higher in probands than siblings or controls, and higher in male siblings than male controls. Autism symptoms were familial, partly shared with familiality of ADHD in males. Latent class analysis using SCQ-score yielded five classes; Class 1(31%) had few autism symptoms and low comorbidity; Classes 2-4 were intermediate; Class 5(7%) had high autism symptoms and comorbidity. Thus autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders.
KW - ADHD
KW - Autism
KW - Familiality
KW - Language disorder
KW - Motor disorder
KW - Oppositional disorders
UR - https://www.scopus.com/pages/publications/58549109197
U2 - 10.1007/s10803-008-0621-3
DO - 10.1007/s10803-008-0621-3
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C2 - 18642069
AN - SCOPUS:58549109197
SN - 0162-3257
VL - 39
SP - 197
EP - 209
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 2
ER -