TY - JOUR
T1 - Autoantibodies against a nuclear 56 kDa protein
T2 - a marker for inflammatory muscle disease
AU - Arad-Dann, Hadas
AU - Isenberg, David
AU - Ovadia, Emi
AU - Shoenfeld, Yehuda
AU - Sperling, Joseph
AU - Sperling, Ruth
PY - 1989/12
Y1 - 1989/12
N2 - Antibodies to a 56 kDa nuclear protein have been found in the sera of 85% of patients with myositis using an immunoblotting technique. This autoantibody appears to be relatively disease-specific though more frequently detectable in both adult and childhood onset dermatomyositis. In adult patients with myositis the anti-56 kDa antibody level reflects disease activity. This antibody is thus much more frequently found than previously described disease-specific autoantibodies in patients with myositis such as the Jo-1 antibody, and may represent a useful diagnostic aid in patients with muscle weakness.
AB - Antibodies to a 56 kDa nuclear protein have been found in the sera of 85% of patients with myositis using an immunoblotting technique. This autoantibody appears to be relatively disease-specific though more frequently detectable in both adult and childhood onset dermatomyositis. In adult patients with myositis the anti-56 kDa antibody level reflects disease activity. This antibody is thus much more frequently found than previously described disease-specific autoantibodies in patients with myositis such as the Jo-1 antibody, and may represent a useful diagnostic aid in patients with muscle weakness.
UR - http://www.scopus.com/inward/record.url?scp=0024779349&partnerID=8YFLogxK
U2 - 10.1016/0896-8411(89)90014-0
DO - 10.1016/0896-8411(89)90014-0
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C2 - 2619871
AN - SCOPUS:0024779349
SN - 0896-8411
VL - 2
SP - 877
EP - 888
JO - Journal of Autoimmunity
JF - Journal of Autoimmunity
IS - 6
ER -