TY - JOUR
T1 - Autoimmune epilepsy
T2 - Distinct subpopulations of epilepsy patients harbor serum autoantibodies to either glutamate/AMPA receptor GluR3, glutamate/NMDA receptor subunit NR2A or double-stranded DNA
AU - Ganor, Yonatan
AU - Goldberg-Stern, Hadassa
AU - Lerman-Sagie, Tally
AU - Teichberg, Vivian I.
AU - Levite, Mia
PY - 2005/6
Y1 - 2005/6
N2 - We studied 82 patients with different types of epilepsy and 49 neurologically intact non-epileptic controls, and identified three different subpopulations of epilepsy patients bearing significantly elevated levels of autoantibodies to either GluR3B-peptide of glutamate/AMPA receptor subtype 3 (17/82; 21% of patients), or to a peptide of NR2A subunit of glutamate/NMDA receptors (15/82; 18%), or to double-stranded (ds) DNA, the hallmark of systemic lupus erythematosus (13/80; 16%). Most patients had only one antibody type, arguing against cross-reactivity. Nearly all anti-dsDNA Ab-positive patients did not harbor anti-nuclear autoantibodies. Most patients had no history of brain damage, febrile convulsions, early onset epilepsy, acute epilepsy or intractable seizures. We suggest to measure the 'autoimmune-fingerprints' of epilepsy patients for diagnostic and therapeutic purposes.
AB - We studied 82 patients with different types of epilepsy and 49 neurologically intact non-epileptic controls, and identified three different subpopulations of epilepsy patients bearing significantly elevated levels of autoantibodies to either GluR3B-peptide of glutamate/AMPA receptor subtype 3 (17/82; 21% of patients), or to a peptide of NR2A subunit of glutamate/NMDA receptors (15/82; 18%), or to double-stranded (ds) DNA, the hallmark of systemic lupus erythematosus (13/80; 16%). Most patients had only one antibody type, arguing against cross-reactivity. Nearly all anti-dsDNA Ab-positive patients did not harbor anti-nuclear autoantibodies. Most patients had no history of brain damage, febrile convulsions, early onset epilepsy, acute epilepsy or intractable seizures. We suggest to measure the 'autoimmune-fingerprints' of epilepsy patients for diagnostic and therapeutic purposes.
KW - Antibodies
KW - Autoimmunity
KW - Double-stranded DNA (dsDNA)
KW - Epilepsy
KW - GluR3
KW - Glutamate receptor
KW - NR2A
UR - http://www.scopus.com/inward/record.url?scp=22844433210&partnerID=8YFLogxK
U2 - 10.1016/j.eplepsyres.2005.03.011
DO - 10.1016/j.eplepsyres.2005.03.011
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C2 - 15978777
AN - SCOPUS:22844433210
SN - 0920-1211
VL - 65
SP - 11
EP - 22
JO - Epilepsy Research
JF - Epilepsy Research
IS - 1-2
ER -