TY - JOUR
T1 - Autoimmunotherapy of Type II diabetes with soluble low-molecular-mass antigens
T2 - A case report
AU - Ginzburg, Michael
AU - Vol, Alexandr
AU - Smirnoff, Patricia
AU - Sandler, Bella
AU - Zusman, Itshak
PY - 2002
Y1 - 2002
N2 - Aims: To study whether autoimmunization of patients suffering from non-insulin-dependent Type II diabetes with soluble low-molecular-mass antigens (LMA) isolated from their serum will activate the immune system and improve clinical status. Materials and methods: From March 1998 to July 2000, the patient was treated, under observation, with LMA isolated from that same patient. Doses for injections varied between 2 and 5 mg of LMA. Injections were performed at weekly or monthly intervals. Biochemical studies were performed before injections and 1 to 2 weeks after them. The following biochemical parameters were determined in the blood: levels of glucose, insulin-competitive auto-antibodies (ICAA), a-glutamine acid decarboxylase (GAD), total concentration of LMA and of the 66 kDa and 51 kDa proteins as main representatives of the LMA isolated. Results: The patient suffered from high blood glucose levels (BGL), ICAA, GAD, hemoglobin Alc and, especially, of LMA and their proteins. Short-arm immunotherapy did not improve the parameters studied. However, a regular monthly injection of LMA at a dose of 3.5 to 4 mg significantly decreased BGL and reduced the concentrations of LMA and their proteins. The whole clinical status of the patient improved and became more stable. Conclusion: We suggest that vaccination of a diabetic patient with LMA activates the host immune system, thereby preventing progress of the disease.
AB - Aims: To study whether autoimmunization of patients suffering from non-insulin-dependent Type II diabetes with soluble low-molecular-mass antigens (LMA) isolated from their serum will activate the immune system and improve clinical status. Materials and methods: From March 1998 to July 2000, the patient was treated, under observation, with LMA isolated from that same patient. Doses for injections varied between 2 and 5 mg of LMA. Injections were performed at weekly or monthly intervals. Biochemical studies were performed before injections and 1 to 2 weeks after them. The following biochemical parameters were determined in the blood: levels of glucose, insulin-competitive auto-antibodies (ICAA), a-glutamine acid decarboxylase (GAD), total concentration of LMA and of the 66 kDa and 51 kDa proteins as main representatives of the LMA isolated. Results: The patient suffered from high blood glucose levels (BGL), ICAA, GAD, hemoglobin Alc and, especially, of LMA and their proteins. Short-arm immunotherapy did not improve the parameters studied. However, a regular monthly injection of LMA at a dose of 3.5 to 4 mg significantly decreased BGL and reduced the concentrations of LMA and their proteins. The whole clinical status of the patient improved and became more stable. Conclusion: We suggest that vaccination of a diabetic patient with LMA activates the host immune system, thereby preventing progress of the disease.
KW - Diabetes
KW - Low-molecular-mass antigens
KW - Therapy
UR - http://www.scopus.com/inward/record.url?scp=0036229149&partnerID=8YFLogxK
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C2 - 11980365
AN - SCOPUS:0036229149
SN - 0258-851X
VL - 16
SP - 71
EP - 72
JO - In Vivo
JF - In Vivo
IS - 1
ER -