Autophosphorylation activates Dictyostelium myosin II heavy chain kinase A by providing a ligand for an allosteric binding site in the α-kinase domain

Keyphrases

• Ab Initio Modeling 33%
• Active Loop 33%
• Alkaline Phosphatase 33%
• Allosteric Activation 33%
• Allosteric Binding Site 100%
• Aspartic Acid 33%
• Atypical Kinase 33%
• Autophosphorylation 100%
• Binding Pocket 33%
• C-terminal Tail 66%
• CAT Activity 66%
• Catalytic Activity 33%
• Conformational Change 33%
• Dephosphorylation 33%
• Dictyostelium 100%
• Dictyostelium Discoideum 33%
• EEF2 33%
• Filament Assembly 33%
• Flex 33%
• Focus of Attention 33%
• Glutamic Acid 33%
• Heavy Chain 100%
• I to 33%
• Kinase Domain 100%
• Kinase Family 33%
• Metazoan 33%
• Mutational Analysis 33%
• Myosin II 100%
• Phosphorylated Peptides 33%
• Phosphothreonine 33%
• Regulatory Mechanism 33%
• Rosetta 33%
• Sequence Alignment 33%
• Shrimp 33%
• Terminal Lobes 33%
• Tethered Ligands 33%
• Threonine 33%

Biochemistry, Genetics and Molecular Biology

• Active Site 33%
• Alkaline Phosphatase 33%
• Animal 33%
• Aspartic Acid 33%
• Autophosphorylation 100%
• Binding Site 100%
• C-Terminus 100%
• Conformational Change 33%
• Dephosphorylation 33%
• Dictyostelium 100%
• Dictyostelium discoideum 33%
• Elongation Factor 2 Kinase 33%
• Enzymatic Activity 33%
• Eukaryotic Elongation Factors 33%
• Glutamic Acid 33%
• Heavy Chain 100%
• Kinase 100%
• Kinase A 100%
• Phosphotransferase 100%
• Sequence Alignment 33%
• Shrimp 33%
• Threonine 33%