TY - JOUR
T1 - Autotomy behavior in rats following peripheral deafferentation is suppressed by daily injections of amitriptyline, diazepam and saline
AU - Seltzer, Zeev
AU - Tal, Michael
AU - Sharav, Yair
PY - 1989/5
Y1 - 1989/5
N2 - Amitriptyline, a tricyclic antidepressant (TCA), was effective in suppressing self-mutilation of a peripherally deafferented hind paw in rats ('autotomy'). This effect was not due to the drug's sedative effect, since locomotor activity was not lower in treated than untreated rats. Daily injections of normal saline also suppressed autotomy, but for a shorter period of time than amitriptyline. This effect was not apparent in diazepam-treated rats, suggesting that the saline injection delayed autotomy as a result of stress-induced anti-nociception. Since amitriptyline is effective in humans in alleviating certain chronic pain disorders, these results further corroborate the suggestion that autotomy is a model of chronic pain, sensitive to centrally acting analgesics and to some forms of stress.
AB - Amitriptyline, a tricyclic antidepressant (TCA), was effective in suppressing self-mutilation of a peripherally deafferented hind paw in rats ('autotomy'). This effect was not due to the drug's sedative effect, since locomotor activity was not lower in treated than untreated rats. Daily injections of normal saline also suppressed autotomy, but for a shorter period of time than amitriptyline. This effect was not apparent in diazepam-treated rats, suggesting that the saline injection delayed autotomy as a result of stress-induced anti-nociception. Since amitriptyline is effective in humans in alleviating certain chronic pain disorders, these results further corroborate the suggestion that autotomy is a model of chronic pain, sensitive to centrally acting analgesics and to some forms of stress.
KW - Amitriptyline
KW - Autotomy
KW - Chronic pain
KW - Diazepam
KW - Peripheral deafferentation
KW - Saline
KW - Stress-induced analgesia
UR - http://www.scopus.com/inward/record.url?scp=0024333520&partnerID=8YFLogxK
U2 - 10.1016/0304-3959(89)90136-X
DO - 10.1016/0304-3959(89)90136-X
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 2748196
AN - SCOPUS:0024333520
SN - 0304-3959
VL - 37
SP - 245
EP - 250
JO - Pain
JF - Pain
IS - 2
ER -