Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties

Paul Farrow, Konstantin Khodosevich, Yechiam Sapir, Anton Schulmann, Muhammad Aslam, Yael Stern-Bach, Hannah Monyer, Jakob von Engelhardt*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

AMPA receptor (AMPAR) function is modulated by auxiliary subunits. Here, we report on three AMPAR interacting proteins—namely CKAMP39, CKAMP52 and CKAMP59—that, together with the previously characterized CKAMP44, constitute a novel family of auxiliary subunits distinct from other families of AMPAR interacting proteins. The new members of the CKAMP family display distinct regional and developmental expression profiles in the mouse brain. Notably, despite their structural similarities they exert diverse modulation on AMPAR gating by influencing deactivation, desensitization and recovery from desensitization, as well as glutamate and cyclothiazide potency to AMPARs. This study indicates that AMPAR function is very precisely controlled by the cell-type specific expression of the CKAMP family members.

Original languageAmerican English
Article numbere09693
JournaleLife
Volume4
Issue numberDecember2015
DOIs
StatePublished - 1 Dec 2015

Bibliographical note

Publisher Copyright:
© Farrow et al.

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