Axonal and presynaptic FMRP: Localization, signal, and functional implications

Xiaoyu Wang, Dalit Sela-Donenfeld, Yuan Wang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Fragile X mental retardation protein (FMRP) binds a selected set of mRNAs and proteins to guide neural circuit assembly and regulate synaptic plasticity. Loss of FMRP is responsible for Fragile X syndrome, a neuropsychiatric disorder characterized with auditory processing problems and social difficulty. FMRP actions in synaptic formation, maturation, and plasticity are site-specific among the four compartments of a synapse: presynaptic and postsynaptic neurons, astrocytes, and extracellular matrix. This review summarizes advancements in understanding FMRP localization, signals, and functional roles in axons and presynaptic terminals.

Original languageAmerican English
Article number108720
JournalHearing Research
StatePublished - 15 Mar 2023

Bibliographical note

Publisher Copyright:
© 2023 Elsevier B.V.


  • Axon projection development
  • Axonal granules
  • Fragile X mental retardation protein
  • Neuropsychiatric disorders
  • Neurotransmitter release
  • RNA-binding proteins


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