Axoplasmic transport block reduces ectopic impulse generation in injured peripheral nerves

Marshall Devor*, Ruth Govrin-Lippmann

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

Afferent fibers ending in nerve end neuromas in rats generate a substantial ectopic discharge and are sensitive to light pressure and to circulating adrenaline. Treatment of the nerve with colchicine or vinblastine at the time of the nerve section resulted in a dose-dependent reduction in the extent of this discharge. Such treatment also reduced neuroma discharge that had already gotten underway.

Original languageEnglish
Pages (from-to)73-85
Number of pages13
JournalPain
Volume16
Issue number1
DOIs
StatePublished - May 1983

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