Azathioprine as a therapeutic alternative for refractory chronic urticaria

Yuval Tal; Ori Toker; Nancy Agmon-Levin; Meir Shalit

doi:10.1111/ijd.12536

Azathioprine as a therapeutic alternative for refractory chronic urticaria

Yuval Tal^*, Ori Toker, Nancy Agmon-Levin, Meir Shalit

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Background: Chronic urticaria (CU) affects up to 1% of the general population. Its impact on quality of life is immense, and patients might require multiple drugs to control symptoms. The main therapeutic challenge in the treatment of CU is to maintain symptomatic control while minimizing the use of glucocorticosteroids and their plethora of side effects. Methods: Two patients with severe, refractory CU after treatment failure with various drugs, including high-dose cyclosporine, were administered azathioprine. Results: In both patients, the treatment with azathioprine resulted in a significant clinical improvement, enabling steroid withdrawal. Conclusion: Azathioprine should be considered as a therapeutic option for chronic, steroid-dependent urticaria, refractory to other treatments.

Original language	English
Pages (from-to)	367-369
Number of pages	3
Journal	International Journal of Dermatology
Volume	54
Issue number	3
DOIs	https://doi.org/10.1111/ijd.12536
State	Published - 1 Mar 2015
Externally published	Yes

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Publisher Copyright:
© 2014 The International Society of Dermatology.

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title = "Azathioprine as a therapeutic alternative for refractory chronic urticaria",

abstract = "Background: Chronic urticaria (CU) affects up to 1% of the general population. Its impact on quality of life is immense, and patients might require multiple drugs to control symptoms. The main therapeutic challenge in the treatment of CU is to maintain symptomatic control while minimizing the use of glucocorticosteroids and their plethora of side effects. Methods: Two patients with severe, refractory CU after treatment failure with various drugs, including high-dose cyclosporine, were administered azathioprine. Results: In both patients, the treatment with azathioprine resulted in a significant clinical improvement, enabling steroid withdrawal. Conclusion: Azathioprine should be considered as a therapeutic option for chronic, steroid-dependent urticaria, refractory to other treatments.",

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AU - Toker, Ori

AU - Agmon-Levin, Nancy

AU - Shalit, Meir

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Y1 - 2015/3/1

N2 - Background: Chronic urticaria (CU) affects up to 1% of the general population. Its impact on quality of life is immense, and patients might require multiple drugs to control symptoms. The main therapeutic challenge in the treatment of CU is to maintain symptomatic control while minimizing the use of glucocorticosteroids and their plethora of side effects. Methods: Two patients with severe, refractory CU after treatment failure with various drugs, including high-dose cyclosporine, were administered azathioprine. Results: In both patients, the treatment with azathioprine resulted in a significant clinical improvement, enabling steroid withdrawal. Conclusion: Azathioprine should be considered as a therapeutic option for chronic, steroid-dependent urticaria, refractory to other treatments.

AB - Background: Chronic urticaria (CU) affects up to 1% of the general population. Its impact on quality of life is immense, and patients might require multiple drugs to control symptoms. The main therapeutic challenge in the treatment of CU is to maintain symptomatic control while minimizing the use of glucocorticosteroids and their plethora of side effects. Methods: Two patients with severe, refractory CU after treatment failure with various drugs, including high-dose cyclosporine, were administered azathioprine. Results: In both patients, the treatment with azathioprine resulted in a significant clinical improvement, enabling steroid withdrawal. Conclusion: Azathioprine should be considered as a therapeutic option for chronic, steroid-dependent urticaria, refractory to other treatments.

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Azathioprine as a therapeutic alternative for refractory chronic urticaria

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