Azithromycin pharmacokinetics in the serum and its distribution to the skin in healthy dogs and dogs with pyoderma

Gila Zur, Stefan Soback, Yfat Weiss, Elad Perry, Eran Lavy, Malka Britzi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Serum and skin tissue azithromycin (AZM) concentrations were analysed in healthy and pyoderma affected dogs to determine AZM pharmacokinetics and to establish the effect of disease on AZM skin disposition. AZM was administered orally to two groups of healthy dogs: (1) at 7.02. mg/kg (n= 7) and (2) at 11.2. mg/kg (n= 9). A crossover design was used on five of them. Seven dogs with pyoderma were treated with AZM at 10.7. mg/kg. The two groups of healthy dogs received AZM once daily over three consecutive days and dogs with pyoderma received the same treatment repeated twice with an interval of 1. week. AZM concentrations were determined by liquid chromatography-tandem mass spectrometry.AZM was rapidly absorbed and slowly excreted. In healthy dogs, maximum serum concentrations appeared 2h after administration and were (mean±standard deviation) 0.60±0.25μg/mL and 1.03±0.43μg/mL, and the half-lives were 49.9±5.10 and 51.9±6.69h for doses of 7.02 and 11.2mg/kg, respectively. Clearance (CL0-24/F) was similar in both dosing groups (1.24±0.24 and 1.29±0.24L/h/kg) and the respective mean residence time (MRT0-24) was 11.1±0.8 and 8.4±2.2h. The skin concentration in healthy dogs was 3.5-6.5 and 5.0-12.0 times higher than the corresponding serum concentration after the two doses and increased after the cessation of AZM administration. The ratio increased significantly in inflamed tissue (9.5-26.2).

Original languageAmerican English
Pages (from-to)122-126
Number of pages5
JournalVeterinary Journal
Volume200
Issue number1
DOIs
StatePublished - Apr 2014

Bibliographical note

Funding Information:
The authors thank Mrs. Tali Bdolah-Abram for performing the statistical analysis. This work was supported in part by Applied Grants of Yissum, The Hebrew University of Jerusalem, Israel.

Keywords

  • Azithromycin
  • Canine
  • Pharmacokinetics
  • Pyoderma
  • Serum
  • Skin

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