B lymphocytes in anti-mycobacterial immune responses: Pathogenesis or protection?

Alexander V. Dyatlov; Alexander S. Apt; Irina A. Linge

doi:10.1016/j.tube.2018.10.011

B lymphocytes in anti-mycobacterial immune responses: Pathogenesis or protection?

Alexander V. Dyatlov
, Alexander S. Apt^*
, Irina A. Linge

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

The role of B cells and antibodies in tuberculosis (TB) immunity, protection and pathogenesis remain contradictory. The presence of organized B cell follicles close to active TB lesions in the lung tissue raises the question about the role of these cells in local host-pathogen interactions. In this short review, we summarize the state of our knowledge concerning phenotypes of B cells populating tuberculous lungs, their secretory activity, interactions with other immune cells and possible involvement in protective vs. pathogenic TB immunity.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Tuberculosis
Volume	114
DOIs	https://doi.org/10.1016/j.tube.2018.10.011
State	Published - Jan 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Ltd

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antibodies
B cell follicles
B lymphocytes
Cytokines
Lung
Mycobacterium tuberculosis

Access to Document

10.1016/j.tube.2018.10.011

Cite this

@article{cdee8434f18e49a7a12da21fa3e44f5d,

title = "B lymphocytes in anti-mycobacterial immune responses: Pathogenesis or protection?",

abstract = "The role of B cells and antibodies in tuberculosis (TB) immunity, protection and pathogenesis remain contradictory. The presence of organized B cell follicles close to active TB lesions in the lung tissue raises the question about the role of these cells in local host-pathogen interactions. In this short review, we summarize the state of our knowledge concerning phenotypes of B cells populating tuberculous lungs, their secretory activity, interactions with other immune cells and possible involvement in protective vs. pathogenic TB immunity.",

keywords = "Antibodies, B cell follicles, B lymphocytes, Cytokines, Lung, Mycobacterium tuberculosis",

author = "Dyatlov, \{Alexander V.\} and Apt, \{Alexander S.\} and Linge, \{Irina A.\}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2019",

month = jan,

doi = "10.1016/j.tube.2018.10.011",

language = "אנגלית",

volume = "114",

pages = "1--8",

journal = "Tuberculosis",

issn = "1472-9792",

}

TY - JOUR

T1 - B lymphocytes in anti-mycobacterial immune responses

T2 - Pathogenesis or protection?

AU - Dyatlov, Alexander V.

AU - Apt, Alexander S.

AU - Linge, Irina A.

PY - 2019/1

Y1 - 2019/1

N2 - The role of B cells and antibodies in tuberculosis (TB) immunity, protection and pathogenesis remain contradictory. The presence of organized B cell follicles close to active TB lesions in the lung tissue raises the question about the role of these cells in local host-pathogen interactions. In this short review, we summarize the state of our knowledge concerning phenotypes of B cells populating tuberculous lungs, their secretory activity, interactions with other immune cells and possible involvement in protective vs. pathogenic TB immunity.

AB - The role of B cells and antibodies in tuberculosis (TB) immunity, protection and pathogenesis remain contradictory. The presence of organized B cell follicles close to active TB lesions in the lung tissue raises the question about the role of these cells in local host-pathogen interactions. In this short review, we summarize the state of our knowledge concerning phenotypes of B cells populating tuberculous lungs, their secretory activity, interactions with other immune cells and possible involvement in protective vs. pathogenic TB immunity.

KW - Antibodies

KW - B cell follicles

KW - B lymphocytes

KW - Cytokines

KW - Lung

KW - Mycobacterium tuberculosis

UR - https://www.scopus.com/pages/publications/85056237248

U2 - 10.1016/j.tube.2018.10.011

DO - 10.1016/j.tube.2018.10.011

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???

C2 - 30711147

AN - SCOPUS:85056237248

SN - 1472-9792

VL - 114

SP - 1

EP - 8

JO - Tuberculosis

JF - Tuberculosis

ER -

B lymphocytes in anti-mycobacterial immune responses: Pathogenesis or protection?

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this