B vitamins and the aging brain

Jacob Selhub*, Aron Troen, Irwin H. Rosenberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

91 Scopus citations


Deficiencies of the vitamins folate, B12, and B6 are associated with neurological and psychological dysfunction and with congenital defects. In the elderly, cognitive impairment and incident dementia may be related to the high prevalence of inadequate B vitamin status and to elevations of plasma homocysteine. Plausible mechanisms include homocysteine neurotoxicity, vasotoxicity, and impaired S-adenosylmethionine-dependent methylation reactions vital to central nervous system function. In light of this, it is imperative to find safe ways of improving vitamin B status in the elderly without exposing some individuals to undue risk.

Original languageAmerican English
Pages (from-to)S112-S118
JournalNutrition Reviews
Issue numberSUPPL. 2
StatePublished - Dec 2010
Externally publishedYes


  • Brain
  • Folate
  • Homocysteine
  • One-carbon metabolism


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