Bacterial GTPase-activating proteins (GAPs) subvert their host's eukaryotic Rho GTPases to their own advantage. Studies of bacterial GAPs extend our understanding of the action of eukaryotic GAPs, provide new tools for studies of cytoskeletal dynamics and offer new targets for anti-bacterial drugs.
Bibliographical noteFunding Information:
We thank Roger Kornberg for stimulatory discussion and helpful comments. This work was supported by grants from NIH (EY-03529), the Israel Science Foundation and the Minerva Foundation.