Bactericidal and cytotoxic effects of sodium hypochlorite and sodium dichloroisocyanurate solutions in vitro

I. Heling*, I. Rotstein, T. Dinur, Y. Szwec-Levine, D. Steinberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

The antimicrobial and cytotoxic effects of sodium hypochlorite (NaOCl) and sodium dichloroisocyanurate (NaDCC) were evaluated and compared in vitro. The minimal inhibitory concentration and minimal bactericidal concentration of NaOCl and NaDCC were tested for Streptococcus sobrinus, Streptococcus salivarius, Enterococcus faecalis, and Streptococcus mutans. The cytotoxic effect was assessed by using human fibroblast tissue culture. Survival rate was assessed by a protein determination method. Results showed that the minimal inhibitory concentration and minimal bactericidal concentration values of NaOCl and NaDCC for the tested bacteria were in a similar range. NaDCC in concentrations higher than 0.02%, and NaOCl in concentrations higher than 0.01% were lethal to fibroblasts. In conclusion it seems that both agents were very effective in killing bacteria, and their cytotoxicity to fibroblasts in tissue culture was similar.

Original languageAmerican English
Pages (from-to)278-280
Number of pages3
JournalJournal of Endodontics
Volume27
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

Bibliographical note

Funding Information:
This study was partially supported by a grant from the Joint Research Fund of the Hebrew University–Hadassah Faculty of Dental Medicine, founded by the Alpha Omega Fraternity and the Hadassah Medical Organization.

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