Bacteriophage isolation from human saliva

Gilad Bachrach*, M. Leizerovici-Zigmond, A. Zlotkin, R. Naor, D. Steinberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

97 Scopus citations


Aims: To detect bacteriophages for Gram-positive oral pathogens in human saliva. Methods and Results: Saliva samples from 31 donors were screened for the presence of bacteriophages for Streptococcus sobrinus, Streptococcus mutans, Streptococcus salivarius, Actinomyces viscosus and Enterococcus faecalis. Bacteriophages for Enterococcus faecalis were found in seven samples. Enterococcus faecalis phages were still present in saliva re-collected from one donor one month, and one year after initial saliva collection. Conclusions: The presence and stability of the Enterococcus faecalis bacteriophages in human saliva suggests a possible role of these bacteriophages in the oral ecosystem. Significance and Impact of the Study: Phage therapy as a way to control oral bacteria might be considered.

Original languageAmerican English
Pages (from-to)50-53
Number of pages4
JournalLetters in Applied Microbiology
Issue number1
StatePublished - 2003

Bibliographical note

Funding Information:
We thank the Direcci6nG eneralde Investigaci6n Cientificay TEcnica (Spain) (Project PB92-0364)fo r financial support.M .T. Moreno thankst he Universi-dad de La Rioja for financials upport.


  • Endodontic treatment failure
  • Enterococcus faecalis
  • Oral bacteriophage
  • Phage therapy
  • Saliva


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