Bacteriophage isolation from human saliva

Gilad Bachrach; M. Leizerovici-Zigmond; A. Zlotkin; R. Naor; D. Steinberg

doi:10.1046/j.1472-765X.2003.01262.x

Bacteriophage isolation from human saliva

Gilad Bachrach^*, M. Leizerovici-Zigmond, A. Zlotkin, R. Naor, D. Steinberg

^*Corresponding author for this work

Institute of Biomedical Research at the Faculty of Dental Medicine

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

Aims: To detect bacteriophages for Gram-positive oral pathogens in human saliva. Methods and Results: Saliva samples from 31 donors were screened for the presence of bacteriophages for Streptococcus sobrinus, Streptococcus mutans, Streptococcus salivarius, Actinomyces viscosus and Enterococcus faecalis. Bacteriophages for Enterococcus faecalis were found in seven samples. Enterococcus faecalis phages were still present in saliva re-collected from one donor one month, and one year after initial saliva collection. Conclusions: The presence and stability of the Enterococcus faecalis bacteriophages in human saliva suggests a possible role of these bacteriophages in the oral ecosystem. Significance and Impact of the Study: Phage therapy as a way to control oral bacteria might be considered.

Original language	English
Pages (from-to)	50-53
Number of pages	4
Journal	Letters in Applied Microbiology
Volume	36
Issue number	1
DOIs	https://doi.org/10.1046/j.1472-765X.2003.01262.x
State	Published - 2003

Bibliographical note

Funding Information:
We thank the Direcci6nG eneralde Investigaci6n Cientificay TEcnica (Spain) (Project PB92-0364)fo r financial support.M .T. Moreno thankst he Universi-dad de La Rioja for financials upport.

Keywords

Endodontic treatment failure
Enterococcus faecalis
Oral bacteriophage
Phage therapy
Saliva

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10.1046/j.1472-765X.2003.01262.x

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title = "Bacteriophage isolation from human saliva",

abstract = "Aims: To detect bacteriophages for Gram-positive oral pathogens in human saliva. Methods and Results: Saliva samples from 31 donors were screened for the presence of bacteriophages for Streptococcus sobrinus, Streptococcus mutans, Streptococcus salivarius, Actinomyces viscosus and Enterococcus faecalis. Bacteriophages for Enterococcus faecalis were found in seven samples. Enterococcus faecalis phages were still present in saliva re-collected from one donor one month, and one year after initial saliva collection. Conclusions: The presence and stability of the Enterococcus faecalis bacteriophages in human saliva suggests a possible role of these bacteriophages in the oral ecosystem. Significance and Impact of the Study: Phage therapy as a way to control oral bacteria might be considered.",

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author = "Gilad Bachrach and M. Leizerovici-Zigmond and A. Zlotkin and R. Naor and D. Steinberg",

note = "Funding Information: We thank the Direcci6nG eneralde Investigaci6n Cientificay TEcnica (Spain) (Project PB92-0364)fo r financial support.M .T. Moreno thankst he Universi-dad de La Rioja for financials upport.",

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doi = "10.1046/j.1472-765X.2003.01262.x",

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AU - Bachrach, Gilad

AU - Leizerovici-Zigmond, M.

AU - Zlotkin, A.

AU - Naor, R.

AU - Steinberg, D.

N1 - Funding Information: We thank the Direcci6nG eneralde Investigaci6n Cientificay TEcnica (Spain) (Project PB92-0364)fo r financial support.M .T. Moreno thankst he Universi-dad de La Rioja for financials upport.

PY - 2003

Y1 - 2003

N2 - Aims: To detect bacteriophages for Gram-positive oral pathogens in human saliva. Methods and Results: Saliva samples from 31 donors were screened for the presence of bacteriophages for Streptococcus sobrinus, Streptococcus mutans, Streptococcus salivarius, Actinomyces viscosus and Enterococcus faecalis. Bacteriophages for Enterococcus faecalis were found in seven samples. Enterococcus faecalis phages were still present in saliva re-collected from one donor one month, and one year after initial saliva collection. Conclusions: The presence and stability of the Enterococcus faecalis bacteriophages in human saliva suggests a possible role of these bacteriophages in the oral ecosystem. Significance and Impact of the Study: Phage therapy as a way to control oral bacteria might be considered.

AB - Aims: To detect bacteriophages for Gram-positive oral pathogens in human saliva. Methods and Results: Saliva samples from 31 donors were screened for the presence of bacteriophages for Streptococcus sobrinus, Streptococcus mutans, Streptococcus salivarius, Actinomyces viscosus and Enterococcus faecalis. Bacteriophages for Enterococcus faecalis were found in seven samples. Enterococcus faecalis phages were still present in saliva re-collected from one donor one month, and one year after initial saliva collection. Conclusions: The presence and stability of the Enterococcus faecalis bacteriophages in human saliva suggests a possible role of these bacteriophages in the oral ecosystem. Significance and Impact of the Study: Phage therapy as a way to control oral bacteria might be considered.

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KW - Enterococcus faecalis

KW - Oral bacteriophage

KW - Phage therapy

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Bacteriophage isolation from human saliva

Abstract

Bibliographical note

Keywords

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