Bacteriophage P2-lambda interference. II. Effects on the host under the control of lambda genes O and P

François Brégégère

doi:10.1016/0022-2836(76)90279-5

Bacteriophage P2-lambda interference. II. Effects on the host under the control of lambda genes O and P

François Brégégère^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Induction of bacteriophage lambda in the presence of a P2 prophage causes a drastic inhibition of protein synthesis through transfer RNA inactivation, and then a shut-off of uridine incorporation. It has also been found to trigger a peculiar process of host killing. We have investigated the dependence of these effects with respect to the genetic determinants of interference. We have shown, moreover, that genes O and P, which control the initiation of phage replication, are required for P2-λ interference. The way the host tRNA can be inactivated through the expression of those genes, which are all concerned with DNA metabolism, is discussed.

Original language	English
Pages (from-to)	411-420
Number of pages	10
Journal	Journal of Molecular Biology
Volume	104
Issue number	2
DOIs	https://doi.org/10.1016/0022-2836(76)90279-5
State	Published - 25 Jun 1976
Externally published	Yes

Access to Document

10.1016/0022-2836(76)90279-5

Cite this

@article{252badac8d1b4a0096d4b9dbe97f6172,

title = "Bacteriophage P2-lambda interference. II. Effects on the host under the control of lambda genes O and P",

abstract = "Induction of bacteriophage lambda in the presence of a P2 prophage causes a drastic inhibition of protein synthesis through transfer RNA inactivation, and then a shut-off of uridine incorporation. It has also been found to trigger a peculiar process of host killing. We have investigated the dependence of these effects with respect to the genetic determinants of interference. We have shown, moreover, that genes O and P, which control the initiation of phage replication, are required for P2-λ interference. The way the host tRNA can be inactivated through the expression of those genes, which are all concerned with DNA metabolism, is discussed.",

author = "Fran{\c c}ois Br{\'e}g{\'e}g{\`e}re",

year = "1976",

month = jun,

day = "25",

doi = "10.1016/0022-2836(76)90279-5",

language = "אנגלית",

volume = "104",

pages = "411--420",

journal = "Journal of Molecular Biology",

issn = "0022-2836",

publisher = "Academic Press",

number = "2",

}

TY - JOUR

T1 - Bacteriophage P2-lambda interference. II. Effects on the host under the control of lambda genes O and P

AU - Brégégère, François

PY - 1976/6/25

Y1 - 1976/6/25

N2 - Induction of bacteriophage lambda in the presence of a P2 prophage causes a drastic inhibition of protein synthesis through transfer RNA inactivation, and then a shut-off of uridine incorporation. It has also been found to trigger a peculiar process of host killing. We have investigated the dependence of these effects with respect to the genetic determinants of interference. We have shown, moreover, that genes O and P, which control the initiation of phage replication, are required for P2-λ interference. The way the host tRNA can be inactivated through the expression of those genes, which are all concerned with DNA metabolism, is discussed.

AB - Induction of bacteriophage lambda in the presence of a P2 prophage causes a drastic inhibition of protein synthesis through transfer RNA inactivation, and then a shut-off of uridine incorporation. It has also been found to trigger a peculiar process of host killing. We have investigated the dependence of these effects with respect to the genetic determinants of interference. We have shown, moreover, that genes O and P, which control the initiation of phage replication, are required for P2-λ interference. The way the host tRNA can be inactivated through the expression of those genes, which are all concerned with DNA metabolism, is discussed.

UR - https://www.scopus.com/pages/publications/0017087120

U2 - 10.1016/0022-2836(76)90279-5

DO - 10.1016/0022-2836(76)90279-5

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 781288

AN - SCOPUS:0017087120

SN - 0022-2836

VL - 104

SP - 411

EP - 420

JO - Journal of Molecular Biology

JF - Journal of Molecular Biology

IS - 2

ER -

Bacteriophage P2-lambda interference. II. Effects on the host under the control of lambda genes O and P

Abstract

Access to Document

Other files and links

Fingerprint

Cite this