Baseline Abdominal Lipid Partitioning Is Associated with the Metabolic Response to Bariatric Surgery

Andrei Keidar; Liat Appelbaum; Chaya Schweiger; Karen Hershkop; Idit Matot; Naama Constantini; Jacob Sosna; Ram Weiss

doi:10.1007/s11695-014-1249-3

Baseline Abdominal Lipid Partitioning Is Associated with the Metabolic Response to Bariatric Surgery

Andrei Keidar, Liat Appelbaum, Chaya Schweiger, Karen Hershkop, Idit Matot, Naama Constantini, Jacob Sosna, Ram Weiss^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Background: The purpose of this study was to compare the effects of two bariatric procedures on abdominal lipid partitioning and metabolic response. Methods: Fifty-one patients (RYGB 31(11 M/20 F); (SG) 20(8 M/12 F)) who met the criteria of metabolic syndrome before the operation were followed following Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG). Visceral and subcutaneous abdominal fat depots were assessed by CT before, 6 months, and 12 months following the operation. Results: Patients undergoing both procedures did not differ in baseline body mass index (BMI) (42.84 ± 4.65 vs. 41.70 ± 4.68 kg/m²) or abdominal lipid depots. BMI at 12 months post-op was similar (29.44 ± 3.35 vs 30.86 ± 4.31 kg/m² for RYGB and SG, respectively). Both procedures led to a significant reduction in visceral and subcutaneous fat at 6 months (p < 0.001 for both). The visceral-to-subcutaneous fat ratio was comparable at 6 months vs. baseline yet was lower at 12 months vs. baseline for both procedures (p < 0.01). In patients who lost the diagnosis of metabolic syndrome, baseline visceral/subcutaneous fat was the only predictor of recovery (p < 0.005). No difference was detected between procedures in dynamics of abdominal fat depots or remission of cardiovascular risk factors. Conclusions: RYGB and SG induce a similar effect on abdominal fat mobilization. The metabolic effects in individual patients are mostly determined by their baseline abdominal lipid partitioning.

Original language	American English
Pages (from-to)	1709-1716
Number of pages	8
Journal	Obesity Surgery
Volume	24
Issue number	10
DOIs	https://doi.org/10.1007/s11695-014-1249-3
State	Published - Oct 2014
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgments The study was funded by the Chief Scientist of the Israel Ministry of Health (RW and AK) and by the Stephen Morse Diabetes research Fund (RW). RW and AK took part in the study design, clinical care, data acquisition, and analysis and writing of the manuscript. All other authors took part in clinical care, data acquisition, and analysis and writing of the manuscript. The guarantor of this work is RW.

Publisher Copyright:
© 2014, Springer Science+Business Media New York.

Keywords

Bariatric surgery
Metabolic syndrome
Subcutaneous fat
Visceral fat

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11695-014-1249-3

Cite this

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title = "Baseline Abdominal Lipid Partitioning Is Associated with the Metabolic Response to Bariatric Surgery",

abstract = "Background: The purpose of this study was to compare the effects of two bariatric procedures on abdominal lipid partitioning and metabolic response. Methods: Fifty-one patients (RYGB 31(11 M/20 F); (SG) 20(8 M/12 F)) who met the criteria of metabolic syndrome before the operation were followed following Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG). Visceral and subcutaneous abdominal fat depots were assessed by CT before, 6 months, and 12 months following the operation. Results: Patients undergoing both procedures did not differ in baseline body mass index (BMI) (42.84 ± 4.65 vs. 41.70 ± 4.68 kg/m2) or abdominal lipid depots. BMI at 12 months post-op was similar (29.44 ± 3.35 vs 30.86 ± 4.31 kg/m2 for RYGB and SG, respectively). Both procedures led to a significant reduction in visceral and subcutaneous fat at 6 months (p < 0.001 for both). The visceral-to-subcutaneous fat ratio was comparable at 6 months vs. baseline yet was lower at 12 months vs. baseline for both procedures (p < 0.01). In patients who lost the diagnosis of metabolic syndrome, baseline visceral/subcutaneous fat was the only predictor of recovery (p < 0.005). No difference was detected between procedures in dynamics of abdominal fat depots or remission of cardiovascular risk factors. Conclusions: RYGB and SG induce a similar effect on abdominal fat mobilization. The metabolic effects in individual patients are mostly determined by their baseline abdominal lipid partitioning.",

keywords = "Bariatric surgery, Metabolic syndrome, Subcutaneous fat, Visceral fat",

author = "Andrei Keidar and Liat Appelbaum and Chaya Schweiger and Karen Hershkop and Idit Matot and Naama Constantini and Jacob Sosna and Ram Weiss",

note = "Funding Information: Acknowledgments The study was funded by the Chief Scientist of the Israel Ministry of Health (RW and AK) and by the Stephen Morse Diabetes research Fund (RW). RW and AK took part in the study design, clinical care, data acquisition, and analysis and writing of the manuscript. All other authors took part in clinical care, data acquisition, and analysis and writing of the manuscript. The guarantor of this work is RW. Publisher Copyright: {\textcopyright} 2014, Springer Science+Business Media New York.",

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month = oct,

doi = "10.1007/s11695-014-1249-3",

language = "American English",

volume = "24",

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T1 - Baseline Abdominal Lipid Partitioning Is Associated with the Metabolic Response to Bariatric Surgery

AU - Keidar, Andrei

AU - Appelbaum, Liat

AU - Schweiger, Chaya

AU - Hershkop, Karen

AU - Matot, Idit

AU - Constantini, Naama

AU - Sosna, Jacob

AU - Weiss, Ram

N1 - Funding Information: Acknowledgments The study was funded by the Chief Scientist of the Israel Ministry of Health (RW and AK) and by the Stephen Morse Diabetes research Fund (RW). RW and AK took part in the study design, clinical care, data acquisition, and analysis and writing of the manuscript. All other authors took part in clinical care, data acquisition, and analysis and writing of the manuscript. The guarantor of this work is RW. Publisher Copyright: © 2014, Springer Science+Business Media New York.

PY - 2014/10

Y1 - 2014/10

N2 - Background: The purpose of this study was to compare the effects of two bariatric procedures on abdominal lipid partitioning and metabolic response. Methods: Fifty-one patients (RYGB 31(11 M/20 F); (SG) 20(8 M/12 F)) who met the criteria of metabolic syndrome before the operation were followed following Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG). Visceral and subcutaneous abdominal fat depots were assessed by CT before, 6 months, and 12 months following the operation. Results: Patients undergoing both procedures did not differ in baseline body mass index (BMI) (42.84 ± 4.65 vs. 41.70 ± 4.68 kg/m2) or abdominal lipid depots. BMI at 12 months post-op was similar (29.44 ± 3.35 vs 30.86 ± 4.31 kg/m2 for RYGB and SG, respectively). Both procedures led to a significant reduction in visceral and subcutaneous fat at 6 months (p < 0.001 for both). The visceral-to-subcutaneous fat ratio was comparable at 6 months vs. baseline yet was lower at 12 months vs. baseline for both procedures (p < 0.01). In patients who lost the diagnosis of metabolic syndrome, baseline visceral/subcutaneous fat was the only predictor of recovery (p < 0.005). No difference was detected between procedures in dynamics of abdominal fat depots or remission of cardiovascular risk factors. Conclusions: RYGB and SG induce a similar effect on abdominal fat mobilization. The metabolic effects in individual patients are mostly determined by their baseline abdominal lipid partitioning.

AB - Background: The purpose of this study was to compare the effects of two bariatric procedures on abdominal lipid partitioning and metabolic response. Methods: Fifty-one patients (RYGB 31(11 M/20 F); (SG) 20(8 M/12 F)) who met the criteria of metabolic syndrome before the operation were followed following Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG). Visceral and subcutaneous abdominal fat depots were assessed by CT before, 6 months, and 12 months following the operation. Results: Patients undergoing both procedures did not differ in baseline body mass index (BMI) (42.84 ± 4.65 vs. 41.70 ± 4.68 kg/m2) or abdominal lipid depots. BMI at 12 months post-op was similar (29.44 ± 3.35 vs 30.86 ± 4.31 kg/m2 for RYGB and SG, respectively). Both procedures led to a significant reduction in visceral and subcutaneous fat at 6 months (p < 0.001 for both). The visceral-to-subcutaneous fat ratio was comparable at 6 months vs. baseline yet was lower at 12 months vs. baseline for both procedures (p < 0.01). In patients who lost the diagnosis of metabolic syndrome, baseline visceral/subcutaneous fat was the only predictor of recovery (p < 0.005). No difference was detected between procedures in dynamics of abdominal fat depots or remission of cardiovascular risk factors. Conclusions: RYGB and SG induce a similar effect on abdominal fat mobilization. The metabolic effects in individual patients are mostly determined by their baseline abdominal lipid partitioning.

KW - Bariatric surgery

KW - Metabolic syndrome

KW - Subcutaneous fat

KW - Visceral fat

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DO - 10.1007/s11695-014-1249-3

M3 - Article

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AN - SCOPUS:84938918088

SN - 0960-8923

VL - 24

SP - 1709

EP - 1716

JO - Obesity Surgery

JF - Obesity Surgery

IS - 10

ER -

Baseline Abdominal Lipid Partitioning Is Associated with the Metabolic Response to Bariatric Surgery

Abstract

Bibliographical note

Keywords

UN SDGs

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