Battle of the midgets: Innate microRNA networking

Shlomo Elias, Ofer Mandelboim*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Natural killer (NK) cells play an important role in the direct killing of cancerous and virus-infected cells. One of the important activating receptors which mediates this killing is NKG2D. This receptor recognizes various stress-induced ligands including the major histocompatibility complex class I-related chain A and B (MICA and MICB respectively). The mechanisms controlling the expression of the NKG2D ligands are not completely understood, yet various studies have demonstrated that the expression of the NKG2D ligands is manipulated by viruses and by tumor cells in order to escape the NKG2D detection. Cumulative data have emphasized that various microRNAs (miRNAs) of both human and viral origin control the expression of NKG2D ligands, particularly MICB. Herein we review recent findings regarding the miRNA regulation of the NKG2D ligands. We propose that these miRNAs generate a complex network of interactions that control the expression of the NKG2D ligands under normal conditions and during disease development.

Original languageAmerican English
Pages (from-to)792-798
Number of pages7
JournalRNA Biology
Volume9
Issue number6
DOIs
StatePublished - Jun 2012

Bibliographical note

Funding Information:
This study was supported by grants from the Israeli Science Foundation (Morasha), The Croatia Israel Research Grant, by the ICRF, by the MOST-DKFZ Research grant, by the Rosetrees trust, by the Israel Cancer Association (20100003), by the Katten foundation and by the Association for International Cancer Research (AICR) (all to O.M.) and by the Hadassah Medical Center physician scientist program (to S.E.). O.M .is a Crown professor of Molecular Immunology.

Keywords

  • MICA
  • MICB
  • NK cells
  • NKG2D
  • ULBP
  • ceRNA
  • miRNA

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