Behavioral Signatures of a Developing Neural Code

Lilach Avitan; Zac Pujic; Jan Mölter; Michael McCullough; Shuyu Zhu; Biao Sun; Ann Elin Myhre; Geoffrey J. Goodhill

doi:10.1016/j.cub.2020.06.040

Behavioral Signatures of a Developing Neural Code

Lilach Avitan, Zac Pujic, Jan Mölter, Michael McCullough, Shuyu Zhu, Biao Sun, Ann Elin Myhre, Geoffrey J. Goodhill^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

During early life, neural codes must develop to appropriately transform sensory inputs into behavioral outputs. Here, we demonstrate a link between the maturity of neural coding in the visual brain and developmental changes in visually guided behavior. In zebrafish larvae, we show that visually driven hunting behavior improves from 4 to 15 days post-fertilization, becoming faster and more accurate. During the same period, population activity in parts of the optic tectum refines, improving decoding and information transmission for particular spatial positions. Remarkably, individual differences in decoding can predict each fish's hunting success. Together, these results help reveal how the neural codes required for a natural behavior emerge during development.

Original language	American English
Pages (from-to)	3352-3363.e5
Journal	Current Biology
Volume	30
Issue number	17
DOIs	https://doi.org/10.1016/j.cub.2020.06.040
State	Published - 7 Sep 2020
Externally published	Yes

Bibliographical note

Funding Information:
We gratefully acknowledge funding from Australian Research Council grants DP170102263 and DP180100636 . Imaging was performed at the Queensland Brain Institute’s Advanced Microscopy Facility using a Zeiss LSM 710 2-photon microscope, generously supported by the Australian Government through the ARC LIEF grant LE130100078 .

Publisher Copyright:
© 2020 Elsevier Inc.

Keywords

behavioral development
calcium imaging
individual differences
mutual information
neural assemblies
neural decoding
neural development
optic tectum
prey capture
zebrafish

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10.1016/j.cub.2020.06.040

Cite this

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title = "Behavioral Signatures of a Developing Neural Code",

abstract = "During early life, neural codes must develop to appropriately transform sensory inputs into behavioral outputs. Here, we demonstrate a link between the maturity of neural coding in the visual brain and developmental changes in visually guided behavior. In zebrafish larvae, we show that visually driven hunting behavior improves from 4 to 15 days post-fertilization, becoming faster and more accurate. During the same period, population activity in parts of the optic tectum refines, improving decoding and information transmission for particular spatial positions. Remarkably, individual differences in decoding can predict each fish's hunting success. Together, these results help reveal how the neural codes required for a natural behavior emerge during development.",

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note = "Funding Information: We gratefully acknowledge funding from Australian Research Council grants DP170102263 and DP180100636 . Imaging was performed at the Queensland Brain Institute{\textquoteright}s Advanced Microscopy Facility using a Zeiss LSM 710 2-photon microscope, generously supported by the Australian Government through the ARC LIEF grant LE130100078 . Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

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doi = "10.1016/j.cub.2020.06.040",

language = "American English",

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AU - Mölter, Jan

AU - McCullough, Michael

AU - Zhu, Shuyu

AU - Sun, Biao

AU - Myhre, Ann Elin

AU - Goodhill, Geoffrey J.

N1 - Funding Information: We gratefully acknowledge funding from Australian Research Council grants DP170102263 and DP180100636 . Imaging was performed at the Queensland Brain Institute’s Advanced Microscopy Facility using a Zeiss LSM 710 2-photon microscope, generously supported by the Australian Government through the ARC LIEF grant LE130100078 . Publisher Copyright: © 2020 Elsevier Inc.

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AB - During early life, neural codes must develop to appropriately transform sensory inputs into behavioral outputs. Here, we demonstrate a link between the maturity of neural coding in the visual brain and developmental changes in visually guided behavior. In zebrafish larvae, we show that visually driven hunting behavior improves from 4 to 15 days post-fertilization, becoming faster and more accurate. During the same period, population activity in parts of the optic tectum refines, improving decoding and information transmission for particular spatial positions. Remarkably, individual differences in decoding can predict each fish's hunting success. Together, these results help reveal how the neural codes required for a natural behavior emerge during development.

KW - behavioral development

KW - calcium imaging

KW - individual differences

KW - mutual information

KW - neural assemblies

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ER -

Behavioral Signatures of a Developing Neural Code

Abstract

Bibliographical note

Keywords

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