Behavioral Signatures of a Developing Neural Code

Lilach Avitan, Zac Pujic, Jan Mölter, Michael McCullough, Shuyu Zhu, Biao Sun, Ann Elin Myhre, Geoffrey J. Goodhill*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

During early life, neural codes must develop to appropriately transform sensory inputs into behavioral outputs. Here, we demonstrate a link between the maturity of neural coding in the visual brain and developmental changes in visually guided behavior. In zebrafish larvae, we show that visually driven hunting behavior improves from 4 to 15 days post-fertilization, becoming faster and more accurate. During the same period, population activity in parts of the optic tectum refines, improving decoding and information transmission for particular spatial positions. Remarkably, individual differences in decoding can predict each fish's hunting success. Together, these results help reveal how the neural codes required for a natural behavior emerge during development.

Original languageAmerican English
Pages (from-to)3352-3363.e5
JournalCurrent Biology
Volume30
Issue number17
DOIs
StatePublished - 7 Sep 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.

Keywords

  • behavioral development
  • calcium imaging
  • individual differences
  • mutual information
  • neural assemblies
  • neural decoding
  • neural development
  • optic tectum
  • prey capture
  • zebrafish

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