TY - JOUR
T1 - Behavioural effects of receptor-specific substance P agonists
AU - Papir-Kricheli, Dalia
AU - Frey, Joseph
AU - Laufer, Ralph
AU - Gilon, Chaim
AU - Chorev, Michael
AU - Selinger, Zvi
AU - Devor, Marshall
PY - 1987/11
Y1 - 1987/11
N2 - Septide and senktide are synthetic substance P (SP) agonists with extremely high selectivity for 1 of the 3 known SP receptor subtypes. When injected intrathecally, they produced dramatically different behavioural effects. Septide, the selective SP-P receptor agonist, evoked intense, compulsive scratching, biting and licking of the hind limb, with no sign of motor flaccidity, and without measurable effect on responses to noxious thermal or mechanical stimulation of the foot or tail. In contrast, senktide, the selective SP-N receptor agonist, produced profound, but transient, motor flaccidity, reduced response to noxious stimuli and, at low doses, 'wet-dog shakes.' These various symptoms, all previously associated with SP and/or synthetic SP analogues, appear therefore to derive from activation of distinct SP receptor subtypes.
AB - Septide and senktide are synthetic substance P (SP) agonists with extremely high selectivity for 1 of the 3 known SP receptor subtypes. When injected intrathecally, they produced dramatically different behavioural effects. Septide, the selective SP-P receptor agonist, evoked intense, compulsive scratching, biting and licking of the hind limb, with no sign of motor flaccidity, and without measurable effect on responses to noxious thermal or mechanical stimulation of the foot or tail. In contrast, senktide, the selective SP-N receptor agonist, produced profound, but transient, motor flaccidity, reduced response to noxious stimuli and, at low doses, 'wet-dog shakes.' These various symptoms, all previously associated with SP and/or synthetic SP analogues, appear therefore to derive from activation of distinct SP receptor subtypes.
KW - Pain
KW - Paralysis
KW - Senktide
KW - Septide
KW - Substance P
KW - Substance P receptor
KW - Tachykinin
KW - Tachykinin receptor
UR - http://www.scopus.com/inward/record.url?scp=0023634483&partnerID=8YFLogxK
U2 - 10.1016/0304-3959(87)90041-8
DO - 10.1016/0304-3959(87)90041-8
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C2 - 2448728
AN - SCOPUS:0023634483
SN - 0304-3959
VL - 31
SP - 263
EP - 276
JO - Pain
JF - Pain
IS - 2
ER -