Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic β-cells via ampk activation

L. Pasternak; E. Meltzer-Mats; G. Babai-Shani; G. Cohen; O. Viskind; J. Eckel; E. Cerasi; S. Sasson; A. Gruzman

doi:10.1039/c4cc03310h

Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic β-cells via ampk activation

L. Pasternak, E. Meltzer-Mats, G. Babai-Shani, G. Cohen, O. Viskind, J. Eckel, E. Cerasi, S. Sasson^*, A. Gruzman

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Adenosine monophosphate-activated protein kinase (AMPK) has been identified as one of the major targets for antidiabetic drugs. This study describes two AMPK-activating agents 2-(benzo[d]thiazol-2-ylmethylthio)-6-ethoxybenzo[d]thiazole and 2-(propylthio)benzo[d]thiazol-6-ol, that increase the rate of glucose uptake in L6 myotubes and also augment glucose-stimulated insulin secretion in INS-1E β-cells and rat islets. We believe that such unique bi-functional compounds can be further used for the development of a new class of antidiabetic drugs.

Original language	English
Pages (from-to)	11222-11225
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	76
DOIs	https://doi.org/10.1039/c4cc03310h
State	Published - 26 Aug 2014

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abstract = "Adenosine monophosphate-activated protein kinase (AMPK) has been identified as one of the major targets for antidiabetic drugs. This study describes two AMPK-activating agents 2-(benzo[d]thiazol-2-ylmethylthio)-6-ethoxybenzo[d]thiazole and 2-(propylthio)benzo[d]thiazol-6-ol, that increase the rate of glucose uptake in L6 myotubes and also augment glucose-stimulated insulin secretion in INS-1E β-cells and rat islets. We believe that such unique bi-functional compounds can be further used for the development of a new class of antidiabetic drugs.",

author = "L. Pasternak and E. Meltzer-Mats and G. Babai-Shani and G. Cohen and O. Viskind and J. Eckel and E. Cerasi and S. Sasson and A. Gruzman",

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T1 - Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic β-cells via ampk activation

AU - Pasternak, L.

AU - Meltzer-Mats, E.

AU - Babai-Shani, G.

AU - Cohen, G.

AU - Viskind, O.

AU - Eckel, J.

AU - Cerasi, E.

AU - Sasson, S.

AU - Gruzman, A.

PY - 2014/8/26

Y1 - 2014/8/26

N2 - Adenosine monophosphate-activated protein kinase (AMPK) has been identified as one of the major targets for antidiabetic drugs. This study describes two AMPK-activating agents 2-(benzo[d]thiazol-2-ylmethylthio)-6-ethoxybenzo[d]thiazole and 2-(propylthio)benzo[d]thiazol-6-ol, that increase the rate of glucose uptake in L6 myotubes and also augment glucose-stimulated insulin secretion in INS-1E β-cells and rat islets. We believe that such unique bi-functional compounds can be further used for the development of a new class of antidiabetic drugs.

AB - Adenosine monophosphate-activated protein kinase (AMPK) has been identified as one of the major targets for antidiabetic drugs. This study describes two AMPK-activating agents 2-(benzo[d]thiazol-2-ylmethylthio)-6-ethoxybenzo[d]thiazole and 2-(propylthio)benzo[d]thiazol-6-ol, that increase the rate of glucose uptake in L6 myotubes and also augment glucose-stimulated insulin secretion in INS-1E β-cells and rat islets. We believe that such unique bi-functional compounds can be further used for the development of a new class of antidiabetic drugs.

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JO - Chemical Communications

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Benzothiazole derivatives augment glucose uptake in skeletal muscle cells and stimulate insulin secretion from pancreatic β-cells via ampk activation

Abstract

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