Abstract
A new fluorescent β-blocker, 9-amino-acridin propranolol (9-AAP), was administered i.v. to rats. Multiple fluorescent 9-AAP binding sites were observed on cardiac muscle cells in frozen sections. Intensity and density of cardiac 9-AAP fluorescence were markedly reduced following pretreatment with (±)- and (-)-propranolol but not with (+)-propranolol. Our findings suggest that 9-AAP may label β-adrenergic receptor sites in rat myocardium.
Original language | English |
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Pages (from-to) | 1387-1389 |
Number of pages | 3 |
Journal | Experientia |
Volume | 32 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1976 |