Beyond splicing: serine–arginine proteins as emerging multifaceted regulators of RNA metabolism in malaria parasites

Manish Goyal, Karina Simantov, Ron Dzikowski

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The serine–arginine-rich (SR) proteins play an exceptionally important role in eukaryotic gene expression, primarily by regulating constitutive and alternative splicing events. In addition to their primary role as splicing factors, SR proteins have emerged as multifunctional RNA-binding proteins that act as key regulators of almost every step of RNA metabolism. As in higher eukaryotes, Plasmodium parasites encode several SR proteins, which were implicated in pre-mRNA splicing. However, only a few have been characterized and their biological roles remain understudied. Intriguingly, in addition to splicing regulation, unexpected functions of particular SR proteins have been reported in Plasmodium in recent years. Here, we highlight the key characteristics and different noncanonical splicing functions of SR proteins and discuss potential mechanisms, which might be involved in their multifaceted functionality in Plasmodium.

Original languageAmerican English
Article number102201
JournalCurrent Opinion in Microbiology
Volume70
DOIs
StatePublished - Dec 2022

Bibliographical note

Funding Information:
RD is supported by Israeli Academy for Science, Israel Science Foundation (ISF) Grant 1523/18 ; Ministry of Science and Technology Grants 3-16285 and 103240 ; the United States – Israel Binational Science Foundation Grant 2019236 . RD is also supported by the Louis M. Leland and Ruth M. Leland Chair in Infectious Diseases.

Publisher Copyright:
© 2022 Elsevier Ltd

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