TY - JOUR
T1 - Bilirubin binding affinity of serum
T2 - comparison of qualitative and quantitative Sephadex gel filtration methods
AU - Kaufmann, N. A.
AU - Kapitulnik, J.
AU - Blondheim, S. H.
PY - 1973
Y1 - 1973
N2 - A simple, 30 min method of estimating the binding of bilirubin to serum protein was compared with a quantitative method. Good correlation was found between the two methods, both based on Sephadex gel filtration. The results indicate that the presence of loosely bound bilirubin can be determined with this simple, qualitative, semimicro scale test. This determination is important for the clinical evaluation of jaundiced infants, since it may help to determine whether and when prophylactic therapy to prevent bilirubin encephalopathy is appropriate.
AB - A simple, 30 min method of estimating the binding of bilirubin to serum protein was compared with a quantitative method. Good correlation was found between the two methods, both based on Sephadex gel filtration. The results indicate that the presence of loosely bound bilirubin can be determined with this simple, qualitative, semimicro scale test. This determination is important for the clinical evaluation of jaundiced infants, since it may help to determine whether and when prophylactic therapy to prevent bilirubin encephalopathy is appropriate.
UR - http://www.scopus.com/inward/record.url?scp=0015898969&partnerID=8YFLogxK
U2 - 10.1093/clinchem/19.11.1276
DO - 10.1093/clinchem/19.11.1276
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C2 - 4758603
AN - SCOPUS:0015898969
SN - 0009-9147
VL - 19
SP - 1276
EP - 1279
JO - Clinical Chemistry
JF - Clinical Chemistry
IS - 11
ER -