TY - JOUR
T1 - Binding of insulin by liposomes incorporating protein
AU - Caygill, C. P.J.
AU - Stein, W. D.
PY - 1969/8/15
Y1 - 1969/8/15
N2 - Various tissues, including rat hemidiaphragms (1,2,3), perfused rat heart (4), rat adipose tissue (5) and frog sartorius muscle (6,7) have been reported to bind insulin. The site of this binding has not been established, but it is believed to be to the cell membrane (8). The experiments reported here were designed to establish with a model system the features necessary for insulin binding. Phospholipid liquid crystals, "liposomes", (9) were found to bind 125I-iodinated insulin when erythrocyte ghosts, with or without prior Triton X-100 solubilisation, were incorporated.
AB - Various tissues, including rat hemidiaphragms (1,2,3), perfused rat heart (4), rat adipose tissue (5) and frog sartorius muscle (6,7) have been reported to bind insulin. The site of this binding has not been established, but it is believed to be to the cell membrane (8). The experiments reported here were designed to establish with a model system the features necessary for insulin binding. Phospholipid liquid crystals, "liposomes", (9) were found to bind 125I-iodinated insulin when erythrocyte ghosts, with or without prior Triton X-100 solubilisation, were incorporated.
UR - http://www.scopus.com/inward/record.url?scp=0014678721&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(69)90098-8
DO - 10.1016/0024-3205(69)90098-8
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C2 - 5803375
AN - SCOPUS:0014678721
SN - 0024-3205
VL - 8
SP - 809
EP - 812
JO - Life Sciences
JF - Life Sciences
IS - 16 PART 2
ER -
