Binding of insulin by liposomes incorporating protein

C. P.J. Caygill; W. D. Stein

doi:10.1016/0024-3205(69)90098-8

Binding of insulin by liposomes incorporating protein

C. P.J. Caygill^*
, W. D. Stein

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Various tissues, including rat hemidiaphragms (1,2,3), perfused rat heart (4), rat adipose tissue (5) and frog sartorius muscle (6,7) have been reported to bind insulin. The site of this binding has not been established, but it is believed to be to the cell membrane (8). The experiments reported here were designed to establish with a model system the features necessary for insulin binding. Phospholipid liquid crystals, "liposomes", (9) were found to bind ¹²⁵I-iodinated insulin when erythrocyte ghosts, with or without prior Triton X-100 solubilisation, were incorporated.

Original language	English
Pages (from-to)	809-812
Number of pages	4
Journal	Life Sciences
Volume	8
Issue number	16 PART 2
DOIs	https://doi.org/10.1016/0024-3205(69)90098-8
State	Published - 15 Aug 1969
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1016/0024-3205(69)90098-8

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AB - Various tissues, including rat hemidiaphragms (1,2,3), perfused rat heart (4), rat adipose tissue (5) and frog sartorius muscle (6,7) have been reported to bind insulin. The site of this binding has not been established, but it is believed to be to the cell membrane (8). The experiments reported here were designed to establish with a model system the features necessary for insulin binding. Phospholipid liquid crystals, "liposomes", (9) were found to bind 125I-iodinated insulin when erythrocyte ghosts, with or without prior Triton X-100 solubilisation, were incorporated.

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Binding of insulin by liposomes incorporating protein

Abstract

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