Binding of monoclonal IgM rheumatoid factor to streptococci via the antibody combining site

A. K. Schröder; A. E. Gharavi; M. Steinitz; P. J.H. Johansson; P. Christensen

doi:10.1159/000234336

Binding of monoclonal IgM rheumatoid factor to streptococci via the antibody combining site

A. K. Schröder^*, A. E. Gharavi, M. Steinitz, P. J.H. Johansson, P. Christensen

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Radiolabelled monoclonal IgM rheumatoid factors, four from patients with type II essential cryoglobulinaemia and one originating from a patient with rheumatoid arthritis, were tested for binding to group A, B, C and G streptococci and Escherichia coli. Two of the preparations exhibited different binding patterns for the streptococci, whereas the remaining three were not reactive. The binding of one of the factors to group A streptococci type 15 was inhibited by F(ab’)₂-fragments of anti-idiotypic antibodies but not anti-IgM Fc or F(ab’)₂of normal rabbit IgG, indicating that the reaction was mediated via the antibody combining sites.

Original language	English
Pages (from-to)	88-91
Number of pages	4
Journal	International Archives of Allergy and Immunology
Volume	83
Issue number	1
DOIs	https://doi.org/10.1159/000234336
State	Published - 1987

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abstract = "Radiolabelled monoclonal IgM rheumatoid factors, four from patients with type II essential cryoglobulinaemia and one originating from a patient with rheumatoid arthritis, were tested for binding to group A, B, C and G streptococci and Escherichia coli. Two of the preparations exhibited different binding patterns for the streptococci, whereas the remaining three were not reactive. The binding of one of the factors to group A streptococci type 15 was inhibited by F(ab{\textquoteright})2-fragments of anti-idiotypic antibodies but not anti-IgM Fc or F(ab{\textquoteright})2of normal rabbit IgG, indicating that the reaction was mediated via the antibody combining sites.",

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AU - Schröder, A. K.

AU - Gharavi, A. E.

AU - Steinitz, M.

AU - Johansson, P. J.H.

AU - Christensen, P.

PY - 1987

Y1 - 1987

N2 - Radiolabelled monoclonal IgM rheumatoid factors, four from patients with type II essential cryoglobulinaemia and one originating from a patient with rheumatoid arthritis, were tested for binding to group A, B, C and G streptococci and Escherichia coli. Two of the preparations exhibited different binding patterns for the streptococci, whereas the remaining three were not reactive. The binding of one of the factors to group A streptococci type 15 was inhibited by F(ab’)2-fragments of anti-idiotypic antibodies but not anti-IgM Fc or F(ab’)2of normal rabbit IgG, indicating that the reaction was mediated via the antibody combining sites.

AB - Radiolabelled monoclonal IgM rheumatoid factors, four from patients with type II essential cryoglobulinaemia and one originating from a patient with rheumatoid arthritis, were tested for binding to group A, B, C and G streptococci and Escherichia coli. Two of the preparations exhibited different binding patterns for the streptococci, whereas the remaining three were not reactive. The binding of one of the factors to group A streptococci type 15 was inhibited by F(ab’)2-fragments of anti-idiotypic antibodies but not anti-IgM Fc or F(ab’)2of normal rabbit IgG, indicating that the reaction was mediated via the antibody combining sites.

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Binding of monoclonal IgM rheumatoid factor to streptococci via the antibody combining site

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