Bio-Inspired Mechanotactic Hybrids for Orchestrating Traction-Mediated Epithelial Migration

Pingqiang Cai; Michael Layani; Wan Ru Leow; Shahrouz Amini; Zhiyuan Liu; Dianpeng Qi; Benhui Hu; Yun Long Wu; Ali Miserez; Shlomo Magdassi; Xiaodong Chen

doi:10.1002/adma.201505300

Bio-Inspired Mechanotactic Hybrids for Orchestrating Traction-Mediated Epithelial Migration

Pingqiang Cai, Michael Layani, Wan Ru Leow, Shahrouz Amini, Zhiyuan Liu, Dianpeng Qi, Benhui Hu, Yun Long Wu, Ali Miserez, Shlomo Magdassi^*, Xiaodong Chen

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

A platform of mechanotactic hybrids is established by projecting lateral gradients of apparent interfacial stiffness onto the planar surface of a compliant hydrogel layer using an underlying rigid substrate with microstructures inherited from 3D printed molds. Using this platform, the mechanistic coupling of epithelial migration with the stiffness of the extracellular matrix (ECM) is found to be independent of the interfacial compositional and topographical cues.

Original language	English
Pages (from-to)	3102-3110
Number of pages	9
Journal	Advanced Materials
Volume	28
Issue number	16
DOIs	https://doi.org/10.1002/adma.201505300
State	Published - 27 Apr 2016

Bibliographical note

Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

3D printing
bio-inspired materials
collective cell migration
mechanotaxis
stiffness gradient

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abstract = "A platform of mechanotactic hybrids is established by projecting lateral gradients of apparent interfacial stiffness onto the planar surface of a compliant hydrogel layer using an underlying rigid substrate with microstructures inherited from 3D printed molds. Using this platform, the mechanistic coupling of epithelial migration with the stiffness of the extracellular matrix (ECM) is found to be independent of the interfacial compositional and topographical cues.",

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AU - Leow, Wan Ru

AU - Amini, Shahrouz

AU - Liu, Zhiyuan

AU - Qi, Dianpeng

AU - Hu, Benhui

AU - Wu, Yun Long

AU - Miserez, Ali

AU - Magdassi, Shlomo

AU - Chen, Xiaodong

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Bio-Inspired Mechanotactic Hybrids for Orchestrating Traction-Mediated Epithelial Migration

Abstract

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Keywords

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