Bio-Inspired Mechanotactic Hybrids for Orchestrating Traction-Mediated Epithelial Migration

Pingqiang Cai, Michael Layani, Wan Ru Leow, Shahrouz Amini, Zhiyuan Liu, Dianpeng Qi, Benhui Hu, Yun Long Wu, Ali Miserez, Shlomo Magdassi*, Xiaodong Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


A platform of mechanotactic hybrids is established by projecting lateral gradients of apparent interfacial stiffness onto the planar surface of a compliant hydrogel layer using an underlying rigid substrate with microstructures inherited from 3D printed molds. Using this platform, the mechanistic coupling of epithelial migration with the stiffness of the extracellular matrix (ECM) is found to be independent of the interfacial compositional and topographical cues.

Original languageAmerican English
Pages (from-to)3102-3110
Number of pages9
JournalAdvanced Materials
Issue number16
StatePublished - 27 Apr 2016

Bibliographical note

Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


  • 3D printing
  • bio-inspired materials
  • collective cell migration
  • mechanotaxis
  • stiffness gradient


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