TY - JOUR
T1 - Bioactive acetylenic metabolites
AU - Kuklev, Dmitry V.
AU - Domb, Abraham J.
AU - Dembitsky, Valery M.
PY - 2013/10/15
Y1 - 2013/10/15
N2 - This article focuses on anticancer, and other biological activities of acetylenic metabolites obtained from plants and fungi. Acetylenic compounds belong to a class of molecules containing triple bond(s). Naturally occurring acetylenics are of particular interest since many of them display important biological activities and possess antitumor, antibacterial, antimicrobial, antifungal, and immunosuppressive properties. There are of great interest for medicine, pharmacology, medicinal chemistry, and pharmaceutical industries. This review presents structures and describes cytotoxic activities of more than 100 acetylenic metabolites, including fatty alcohols, ketones, and acids, acetylenic cyclohexanoids, spiroketal enol ethers, and carotenoids isolated from fungi and plants.
AB - This article focuses on anticancer, and other biological activities of acetylenic metabolites obtained from plants and fungi. Acetylenic compounds belong to a class of molecules containing triple bond(s). Naturally occurring acetylenics are of particular interest since many of them display important biological activities and possess antitumor, antibacterial, antimicrobial, antifungal, and immunosuppressive properties. There are of great interest for medicine, pharmacology, medicinal chemistry, and pharmaceutical industries. This review presents structures and describes cytotoxic activities of more than 100 acetylenic metabolites, including fatty alcohols, ketones, and acids, acetylenic cyclohexanoids, spiroketal enol ethers, and carotenoids isolated from fungi and plants.
KW - Acetylenic metabolits
KW - Acids
KW - Antibacterial Fatty alcohols
KW - Antifungal
KW - Antitumor
KW - Carotenoids
KW - Cyclohexanoids
KW - Fungi
KW - Plants
KW - Polyacetylenes
KW - Polyynes
UR - http://www.scopus.com/inward/record.url?scp=84884210912&partnerID=8YFLogxK
U2 - 10.1016/j.phymed.2013.06.009
DO - 10.1016/j.phymed.2013.06.009
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C2 - 23871125
AN - SCOPUS:84884210912
SN - 0944-7113
VL - 20
SP - 1145
EP - 1159
JO - Phytomedicine
JF - Phytomedicine
IS - 13
ER -