TY - JOUR
T1 - Bioactive compounds and antioxidant and antiproliferative activities of korean white lotus cultivars
AU - Park, Yong Seo
AU - Towantakavanit, Korsak
AU - Kowalska, Teresa
AU - Jung, Soon Teck
AU - Ham, Kyung Sik
AU - Heo, Buk Gu
AU - Cho, Ja Yong
AU - Yun, Jae Gill
AU - Kim, Hyun Ju
AU - Gorinstein, Shela
PY - 2009/10/1
Y1 - 2009/10/1
N2 - In traditional Korean medicine, lotus (Nelumbo nucifera Gaertn) roots have been used as an antidiabetic and an antiproliferative remedy. However, scientific publications on lotus properties are very limited. Therefore, it was decided to investigate the Korean white lotus cultivars in order to find out their bioactivity. It was found that all lotus cultivars (Inchisa, Muan, Garam, and Chungyang) possess high amounts of bioactive compounds: total phenols, between 7.95±0.8 and 4.21±0.3mg of gallic acid equivalents (GAE)/g dry weight (DW); ascorbic acid, between 15.8±1.1 and 22.3±1.7mg of ascorbic acid/g DW; and amino acids, between 15.05±0.82% and 16.62±0.90% DW. The highest contents of polyphenols (7.95±0.8mg of GAE/g DW) and the highest levels of antioxidant [by 2,2-azino-bis(3- ethylbenzthiazoline-6-sulfonic acid) and 1,1-diphenyl-2-picrylhydrazyl assays, 54.27±6.1 and 21.98±2.5μM Trolox equivalents/g DW, respectively] and antiproliferative activities on both human cancer cell lines (Calu-6 for human pulmonary carcinoma and SMU-601 for human gastric carcinoma, 59.75±3.99% and 71.21±2.79% cell viability, respectively) were found in the Chungyang cultivar. Fluorometry and Fourier transform infrared spectroscopy can be applied as rapid methods for determination of bioactive compounds, such as polyphenols. The correlation between the bioactive compounds and the antioxidant activity was high. In conclusion, all Korean white lotus cultivars are valuable medicinal foods, and in order to receive the best results a combination of lotus cultivars has to be consumed.
AB - In traditional Korean medicine, lotus (Nelumbo nucifera Gaertn) roots have been used as an antidiabetic and an antiproliferative remedy. However, scientific publications on lotus properties are very limited. Therefore, it was decided to investigate the Korean white lotus cultivars in order to find out their bioactivity. It was found that all lotus cultivars (Inchisa, Muan, Garam, and Chungyang) possess high amounts of bioactive compounds: total phenols, between 7.95±0.8 and 4.21±0.3mg of gallic acid equivalents (GAE)/g dry weight (DW); ascorbic acid, between 15.8±1.1 and 22.3±1.7mg of ascorbic acid/g DW; and amino acids, between 15.05±0.82% and 16.62±0.90% DW. The highest contents of polyphenols (7.95±0.8mg of GAE/g DW) and the highest levels of antioxidant [by 2,2-azino-bis(3- ethylbenzthiazoline-6-sulfonic acid) and 1,1-diphenyl-2-picrylhydrazyl assays, 54.27±6.1 and 21.98±2.5μM Trolox equivalents/g DW, respectively] and antiproliferative activities on both human cancer cell lines (Calu-6 for human pulmonary carcinoma and SMU-601 for human gastric carcinoma, 59.75±3.99% and 71.21±2.79% cell viability, respectively) were found in the Chungyang cultivar. Fluorometry and Fourier transform infrared spectroscopy can be applied as rapid methods for determination of bioactive compounds, such as polyphenols. The correlation between the bioactive compounds and the antioxidant activity was high. In conclusion, all Korean white lotus cultivars are valuable medicinal foods, and in order to receive the best results a combination of lotus cultivars has to be consumed.
KW - Antioxidant and antiproliferative activities
KW - Bioactive compounds
KW - Korean white lotus cultivars
UR - http://www.scopus.com/inward/record.url?scp=70350513284&partnerID=8YFLogxK
U2 - 10.1089/jmf.2009.0018
DO - 10.1089/jmf.2009.0018
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C2 - 19857070
AN - SCOPUS:70350513284
SN - 1096-620X
VL - 12
SP - 1057
EP - 1064
JO - Journal of Medicinal Food
JF - Journal of Medicinal Food
IS - 5
ER -