Bioactivities of phenolic compounds from kiwifruit and persimmon

Young Mo Kim, Faridah Abas, Yong Seo Park, Yang Kyun Park, Kyung Sik Ham, Seong Gook Kang, Martyna Lubinska-Szczygeł, Aviva Ezra, Shela Gorinstein*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Fruit used in the common human diet in general, and kiwifruit and persimmon particularly, displays health properties in the prevention of heart disease. This study describes a combination of bioactivity, multivariate data analyses and fluorescence measurements for the differentiating of kiwifruit and persimmon, their quenching and antioxidant properties. The metabolic differences are shown, as well in the results of bioactivities and antioxidant capacities determined by ABTS, FRAP, CUPRAC and DPPH assays. To complement the bioactivity of these fruits, the quenching properties between extracted polyphenols and human serum proteins were determined by 3D-fluorescence spectroscopy studies. These properties of the extracted polyphenols in interaction with the main serum proteins in the human metabolism (human serum albumin (HSA), α-β-globulin (α-β G) and fibrinogen (Fgn)), showed that kiwifruit was more reactive than persimmon. There was a direct correlation between the quenching properties of the polyphenols of the investigated fruits with serum human proteins, their relative quantification and bioactivity. The results of metabolites and fluorescence quenching show that these fruits possess multiple properties that have a great potential to be used in industry with emphasis on the formulation of functional foods and in the pharmaceutical industry. Based on the quenching properties of human serum proteins with polyphenols and recent reports in vivo on human studies, we hypothesize that HSA, α-β G and Fgn will be predictors of coronary artery disease (CAD).

Original languageEnglish
Article number4405
JournalMolecules
Volume26
Issue number15
DOIs
StatePublished - 1 Aug 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors.

Keywords

  • Biomarkers
  • Human serum proteins
  • Kiwifruit
  • Persimmon
  • Polyphenols
  • Quenching properties

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