Biocatalytic growth of Au nanoparticles immobilized on glucose oxidase enhances the ferrocene-mediated bioelectrocatalytic oxidation of glucose

A study was conducted to investigate the electrical contacting between glucose oxidase and the electrode by biocatalytic enlargement of Au nanoparticles (NPs) tethered to the enzyme electrode. The study observed that the enlargement of the NPs can improve the interfacial electron transfer and bioelectrocatalyzed oxidation of glucose. The study also found that the electron transfer can take place between glucose oxidase and the electrode by the deposition of ferrocene redox-active relay units on the NPs. The study used modification of the enzyme with metallic NPs and the biocatalytic optimization of the electrical contact by the biocatalytic growth of the NPs. It was observed that the enlarged particles can improve the electrical conductance at the electrode surfaces and electron transfer between enzyme redox center and electrode.