TY - JOUR
T1 - Biodegradable polymers derived from amino acids
AU - Khan, Wahid
AU - Muthupandian, Saravanan
AU - Farah, Shady
AU - Kumar, Neeraj
AU - Domb, Abraham J.
PY - 2011/12/8
Y1 - 2011/12/8
N2 - In the past three decades, the use of polymeric materials has increased dramatically for biomedical applications. Many α-amino acids derived biodegradable polymers have also been intensely developed with the main goal to obtain bio-mimicking functional biomaterials. Polymers derived from α-amino acids may offer many advantages, as these polymers: (a) can be modified further to introduce new functions such as imaging, molecular targeting and drugs can be conjugated chemically to these polymers, (b) can improve on better biological properties like cell migration, adhesion and biodegradability, (c) can improve on mechanical and thermal properties and (d) their degradation products are expected to be non-toxic and readily metabolized/excreted from the body. This manuscript focuses on biodegradable polymers derived from natural amino acids, their synthesis, biocompatibility and biomedical applications. It is observed that polymers derived from α-amino acids constitute a promising family of biodegradable materials. These provide innovative multifunctional polymers possessing amino acid side groups with biological activity and with innumerous potential applications.
AB - In the past three decades, the use of polymeric materials has increased dramatically for biomedical applications. Many α-amino acids derived biodegradable polymers have also been intensely developed with the main goal to obtain bio-mimicking functional biomaterials. Polymers derived from α-amino acids may offer many advantages, as these polymers: (a) can be modified further to introduce new functions such as imaging, molecular targeting and drugs can be conjugated chemically to these polymers, (b) can improve on better biological properties like cell migration, adhesion and biodegradability, (c) can improve on mechanical and thermal properties and (d) their degradation products are expected to be non-toxic and readily metabolized/excreted from the body. This manuscript focuses on biodegradable polymers derived from natural amino acids, their synthesis, biocompatibility and biomedical applications. It is observed that polymers derived from α-amino acids constitute a promising family of biodegradable materials. These provide innovative multifunctional polymers possessing amino acid side groups with biological activity and with innumerous potential applications.
KW - Amino acids
KW - Biocompatibility
KW - Biodegradable polymers
KW - Biomaterials
KW - Functional polymers
UR - http://www.scopus.com/inward/record.url?scp=83255185851&partnerID=8YFLogxK
U2 - 10.1002/mabi.201100324
DO - 10.1002/mabi.201100324
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C2 - 22052719
AN - SCOPUS:83255185851
SN - 1616-5187
VL - 11
SP - 1625
EP - 1636
JO - Macromolecular Bioscience
JF - Macromolecular Bioscience
IS - 12
ER -