Abstract
The importance of sex differences in neurological disorders has been increasingly acknowledged in recent clinical and basic research studies, but the complex biology and genetics underlying sex-linked biological heterogeneity and its brain-to-body impact remained incompletely understood. Men and women differ substantially in their susceptibility to certain neurological diseases, in the severity of symptoms, prognosis as well as the nature and efficacy of their response to treatments. The detailed mechanisms underlying these differences, especially at the molecular level, are being addressed in many studies but leave a lot to be further revealed. Here, we provide an overview of recent advances in our understanding of how sex differences in the brain and brain-body signaling contribute to neurological disorders and further present some future prospects entailed in terms of diagnostics and therapeutics.
| Original language | English |
|---|---|
| Title of host publication | Sex and Gender Differences in Neurological Disease |
| Editors | Elena Moro, Gennarina Arabia, Maria Carmela Tartaglia, Maria Carmela Tartaglia, Maria Carmela Tartaglia, Maria Teresa Ferretti |
| Publisher | Academic Press Inc. |
| Pages | 27-67 |
| Number of pages | 41 |
| ISBN (Print) | 9780323915892 |
| DOIs | |
| State | Published - Jan 2022 |
Publication series
| Name | International Review of Neurobiology |
|---|---|
| Volume | 164 |
| ISSN (Print) | 0074-7742 |
| ISSN (Electronic) | 2162-5514 |
Bibliographical note
Publisher Copyright:© 2022 Elsevier Inc.
Keywords
- Brain-body communication
- Epigenetic mechanisms
- Neurological disease
- Sex chromosomes
- Sex differences
- Sex hormones